内质网应激与动脉粥样硬化的研究进展-中国细胞生物学学报.PDF

中国细胞生物学学报 Chinese Journal of Cell Biology 2017, 39(4): 472–480 DOI: 10.11844/cj cb.2017.04.0198 综述 内质网应激与动脉粥样硬化的研究进展 裴芊芊 曾子谦 董丽华* (河北医科大学基础医学院生物化学与分子生物学教研室, 河北省医学生物技术重点实验室, 神经与血管生物学省部共建教育部重点实验室, 石家庄050017) 摘要 内质网应激是指细胞在缺血、氧化应激、钙稳态紊乱、蛋白质折叠错误或正常蛋白 质表达增强等条件下发生的一系列适应性的保护反应。越来越多的研究表明, 内质网应激在动脉 粥样硬化发展的所有阶段均具有重要作用。该文主要综述了动脉管壁不同类型的细胞中内质网应 激和细胞凋亡在动脉粥样硬化发展中的作用, 并总结了目前调节这些途径的靶向分子以及它们在 动脉粥样硬化治疗中的潜在疗效。 关键词 内质网应激; 动脉粥样硬化; 血管内皮细胞; 血管平滑肌细胞; 巨噬细胞 Progress of Endoplasmic Reticulum Stress Related to Atherosclerosis Pei Qianqian, Zeng Ziqian, Dong Lihua* (Department of Biochemistry and Molecular Biology, Institute of Basic Medicine, Key Laboratory for Medical Biotechnology of Hebei Province, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang 050017, China) Abstract The endoplasmic reticulum (ER) is a complex cytoplasmic membrane structure presented in eukaryotic cells, involving in protein folding, lipid synthesis and regulation of the intracellular calcium balance. The capacity of protein folding in ER can be saturated, then induce ER stress (ERS) response. The accumulating evidence demonstrates that ERS and associated apoptosis can be induced in the pathological conditions of atherosclerotic lesions and contribute to the disease progression. Notably, they may play a role in the development of vulnerable plaques that induce thrombosis and are therefore especially dangerous. ERS response is regulated by several signaling mechanisms that involve protein kinases and transcription factors. Some of these molecules can be regarded as potential therapeutic targets to improve treatment of atherosclerosis. Keywords