NLRP3炎性小体与系统性红斑狼疮的相关研究.pdfVIP

Advances in Clinical Medicine 临床医学进展, 2018, 8(6), 544-548 Published Online August 2018 in Hans. /journal/acm /10.12677/acm.2018.86090 Related Research on NLRP3 Inflammasome and SLE 1 2 1* Jiani Wang , Huiqin Cao , Yuhong Liu 1 Department of Rheumatology, Affiliated Hospital of Yan’an University, Yan’an Shaanxi 2 Department of Hematology, Affiliated Hospital of Yan’an University, Yan’an Shaanxi th nd th Received: Jul. 12 , 2018; accepted: Aug. 2 , 2018; published: Aug. 9 , 2018 Abstract NLRP3 is one of the members of NOD and belongs to a typical representative in NLR family. In- flammasome of NLRP3 is able to activate caspase-1 and further shears IL-1β, IL-18 precusor, to make them active proinflammatory factor which will be released in order to participate in the immune response in organism’s resistance to pathogene. Recent researches showed that SLE pa- tients’ serum levels of IL-1β and IL-18 about SLE patients were elevated and these levels are closely related to the severity of SLE. This article summarizes the structure and activation method of NLRP3 as well as its research progress with SLE so as to search for more accurate targeted therapy approach which can be a reference. Keywords Inflammasome, SLE Disease, Summary NLRP3炎性小体与系统性红斑狼疮的相关研究 1 2 1* 王嘉妮 ，曹慧琴 ，刘宇宏 1延安大学附属医院免疫风湿科，陕西 延安 2延安大学附属医院血液免疫科，陕西 延安 收稿日期：2018年7月12 日；录用日期：2018年8月2 日；发布日期：2018年8月9 日 摘 要 核苷酸结合寡聚化结构域样受体3 (NLRP3) ，是胞质型模式识别受体NOD样受体(pyrin domain con-