基于三维周期性极小化曲面的骨组织支架建模方法研究-机械电子工程专业论文.docxVIP

哈尔滨工业大学工学硕士学位论文 哈尔滨工业大学工学硕士学位论文 - - II - Abstract Signal molecules (growth factor, inducing factor), tissue scaffold and inducing cells constitute the three elements of bone tissue engineering scaffold, in which the design and manufacturing of scaffold is the core of the entire field of study. In the process of the bone construction, scaffold carries the signal molecules and induced cells, guiding these cells proliferation and differentiation to form a specific shape. However, porosity and pore size have a great impact on the bracket of these properties, so the porosity and pore size should be inevitably maintained at an appropriate range when the three-dimensional bone tissue engineering scaffolds are built. This paper studies the construction methods of bone tissue engineering scaffold from the following aspects, ensuring that the relevant elements of the scaffold can meet certain requirements. Developing a slicing algorithm which can slice various three dimensional models with different heights, and ordering the contour line segments got after the cutting layer in an certain rules (anti-clock wise or clockwise), getting a container contains the topology information of contour. A new scaffold pore unit-TPMS (Triply Periodic Minimal Surface) is discussed, and its construction method is also described.The feasibility TPMS can be used as the pore unit is also determinated. The relationship between the related design parameters of pore-forming unit and porosity and pore size is determined. In according to this relationship, the pore-forming unit can be designed, meeting actual requirements. According to the various two dimensional section profile after 3D model sliced, the corresponded filling algorithm, resulting in filling data which not only keep the whole appearance of the mode, but also contain its internal topology information. The software used to construct bone tissue engineering scaffold is developed on the platform of VC++6.0 combined with OpenGL technology.