光动力疗法治疗BCC及SCC的临床疗效观察皮肤病学与性病学专业论文.docxVIP

宁夏医科大学硕士研究生学位论文英文摘要 宁夏医科大学硕士研究生学位论文 英文摘要 宁夏医科大学硕士研究生学位论文英文摘要 宁夏医科大学硕士研究生学位论文 英文摘要 PAGE PAGE IV III III The Clinical Research of Photodynamics on Therapy of BCC and SCC ABSTRACT Objective To investigate 5-ALA-PDT’s clinical curative effect,security and recurrence rate is in the aspect of BCC and SCC. Method to observe the curative effect of clinical anterior-posterior therapy, to some pa- tient who have comparatively large cancer or comparatively deep imbibitions could use lique- frozen before every therapy.The course of treatment is 4 to 8 weeks.We could valuate the cur-ative effect after the last therapy and observe recurrence rate and adverse reaction after the se- quential 3,6,9 and 24monthes. Result 19 patients were complete response in 36 patients, cure rate was 52.8%,including 14 patients of superficial type BCC and 5 patients of micronodular BCC.Partial response rate was 25.0%,the overall response rate was 86.1% and inefficiency was 13.9%. Still in follow-up, currently temporary did not found recurrence patients. Conclusion The external method of ALA-PDT have some difference in aspect of clini- cal curative effect of BCC and SCC.The superficial type BCC have higher recovery rate.This method is effective to nodular type BCC,but have lower recovery rate.So to suggest some pa- tients who have some privileged site such as honor or requestion of cosmetology and not tole- rance operative could firstly choose ALA-PDT.This method could become preoperotive pre- paration therapy to some patients who have comparatively large and cannot surgical ablation. To SCC,the clinical curative effect is not optimism,so we could need to observe in further. Key Words ALA-PDT，BCC，SCC 宁夏医科大学硕士研究生学位论文中英文缩略词表 宁夏医科大学硕士研究生学位论文 中英文缩略词表 宁夏医科大学硕士研究生学位论文目录 宁夏医科大学硕士研究生学位论文 目录 中英文缩略词表 ALA-PDT 5-aminolevulinic acid-photodynamic therapy 艾拉-光动力治疗 PDT photodynamic therapy 光动力学治疗 ALA Aminolevulinic Acid 盐酸氨酮戊酸 BCC basal cell carcinoma 基底细胞癌 SCC squamous cell carcinoma 鳞状细胞癌 CR complete response 完