冠心病患者血清IL-17与vWF、CRP水平及冠脉病变程度的相关性-内科学(心血管病学)专业论文.docxVIP

II II 英文摘要 冠心病患者血清白介素-17 与血管假友病因子、C-反应蛋白水平及冠脉病变程度的相关性 The correlation between IL-17 with serum vWF、CRP and the severity of coronary lesion in coronary heart disease patients Abstract Objective: To investigate the changes and the clinical significance of interleukin-17(IL-17)、vascular False Friends of the etiology sub(vWF) and C-reactive protein(CRP) in the serum of patients with coronary heart disease(CHD); and to observe the relation among IL-17、vWF and CRP. At last, to evaluate the influence of IL-17 to CHD. Methods: The 65 cases of patients with clinical symptoms of coronary heart disease were diagnosed by the selective coronary angiography (CAG) method. All the cases were divided into four groups: the 23 cases of patients with stable angina pectoris serve as SAP group , the 14 cases of patients with unstable angina pectoris serve as UAP group, the 25 cases of patients with myocardial infarction serve as AMI group, and the 28 cases of healthy people serve as control group(C group).The concentration levels of IL -17 and vWF in the serum were detected by the enzyme-linked immunoassay (ELISA)method, and the CRP content was tested by the immune scattering nephelometry detection. the severity of Coronary artery lesion was evaluated with the Gensini score system. Finally, the inner link among IL-17 、vWF、CRP and Gensini score was analysed . Results: The IL-17, vWF, CRP levels in the serum of patients with coronary artery disease are significantly higher than those in normal control group (P0.05),and the IL-17, vWF, CRP levels in the AMI group and UAP group are significantly higher than that in the SAP group, The results of all the data have statistical significance.IL-17 have positive correlation with vWF (r=0.610,P0.001)and CRP (r=0.568,P0.001),as well as with Gensini score(r=0.438,P0.001). Conclusion: IL-17, vWF and CRP are involved in the occurrence and development of coronary heart disease , and IL-17 which closely related with the severity of coronary III III 冠心病患者