桂苓消异方对子宫内膜异位症在位内膜基质细胞作用机理的分析-中西医结合临床专业论文.docxVIP

扬州大学硕士学位论文 PAGE 4 扬州大学硕士学位论文 PAGE 4 赖秋红 赖秋红 桂苓消异方对子宫内膜异位症在位内膜基质细胞作用机理的研究 PAGE 5 The experimental study on the mechanism of Guiling xiaoyi decoction on eutopic stromal-cell in endometriosis ABSTRACT Endometriosis is a common and frequently-occurring gynecological disease which defined as endometriotic tissues growing outside the normal uterine cavity.Endometriosis often causes dysmenorrhea, dyspareunia and infertility. The incidence has showed rising trend in recent years. Endometriosis is not only wide range of lesions, morphological diversity, but also has malignant biological characteristics, such as transfer, infiltration and recurrence. Because the pathogenesis of endometriosis has not been fully clarified leading to poor targeted therapies, clinical treatment shows some features with high recurrent, serious side effects at present. This object focused on the study of the theoretical foundation about the treatment by Guiling xiaoyi Decoction. By established the in-vitro cultural method of purified stromal-cell, we observed the effect of drug serum of Guiling xiaoyi Decoction on morphology and MMP-9 secretion of stromal cells in vitro. We have already confirmed that Guiling xiaoyi decoction could inhibit IL-6 and IL-8 secretion of endometrial stromal cells in vitro from patient with endometriosis. In order to explore the role of IL-6, IL-8 in the process of endometriosis and the mechanism of Guiling xiaoyi Decoction on endometriosis, further studies were carried out whether there are correlation between IL-6, IL-8 and MMP-9 secretion of endometrial stromal cells, based on the preparatory work. The study of the theoretical basis of the treatment of Guiling xiaoyi decoction for dometriosis According to the cardinal symptoms of endometriosis, endometriosis belongs to those of algomenorrhea, abdominal mass and infertility in traditional Chinese medicine. This disease is due to malfunction of the dominating reproduction of the kidney, frequent sexual intercourse du