含重组人骨形态发生蛋白-2骨修复材料在颈椎前路减压植骨融合术中的应用-骨外科专业论文.docxVIP

PAGE PAGE IV 含重组人骨形态发生蛋白-2 骨修复材料在颈椎前路减压植骨融合术中的应用 英文摘要 Application of bone repair material containing recombinant human bone morphogenetic protein-2 in anterior cervical discectomy and fusion Abstract Objective The present retrospective study was conducted to compare the clinical and radiographic outcomes in patients who had underwent anterior cervical discectomy with fusion (ACDF) using polyetheretherketone (PEEK) cages packed with bone repair material containing recombinant human bone morphogenetic protein-2 with autologous iliac crest. Methods From March 2011 to July 2012, a total of 40 consecutive patients with cervical spinal degenerative disease who had underwent anterior cervical discectomy with fusion at the department of the First Affiliated Hospital of Soochow University with a minimum of 12-month follow-up comprised study population. Indications for surgery included radiculopathy or myelopathy due to the nerve root or spinal cord compression. We retrospectively reviewed cases of ACDF using PEEK cages packed with bone repair material containing recombinant human bone morphogenetic protein-2 and autologous osteophyte in 21 patients, and autologous iliac crest in 19 who had sequential radiographs before and after surgery, and 1 year after operation. The anterior disc height (ADH), interbody height (IBH), segmental interbody angle (IBA) and fusion status were assessed on radiographs including flexion/extension radiographs and CT Scan.The neurologic outcomes were evaluated using the VAS score for neck and arm pain and the Japanese Orthopedic Association scoring system for myelopathy. Results Baseline demographic data showed no significant difference between groups （p 0.05）. At the last follow-up, solid fusion appeared to have been achieved in patients of both groups. Lordosis was increased significantly in both groups after surgery (p 0.001 in rhBMP-2 and p 0.001 in ICBG), and was maintained up until 1year (p 0.016 英文摘要 含重组人骨形态发生蛋白-2 骨修复材料在颈椎前路减压植骨融合中的应用