冠心病秽浊痰阻证与血管内皮损伤的关系研究-中医内科学专业论文.docxVIP

— — PAGE 1— 摘 要 冠心病秽浊痰阻证与血管内皮损伤的关系研究 研究生：付晓乐 导师：安冬青 教授 摘 要 目的：通过对血浆内皮素(ET)、血浆血栓调节蛋白(TM)的含量变化观察，初步 探讨冠心病秽浊痰阻证与血管内皮损伤之间的关系，进一步为制定冠心病秽浊痰阻 证的诊断标准提供微观的客观依据，使冠心病秽浊痰阻证的诊断趋于客观化。方法： 选取冠心病秽浊痰阻证 84 例、冠心病非秽浊痰阻证 88 例、健康对照组 78 例；观察 三组一般资料及血浆内皮素(ET)、血浆血栓调节蛋白(TM)的含量的变化。结果：1） 血浆 ET 含量的比较：与健康对照组相比，冠心病秽浊痰阻证组、非秽浊痰阻证组患 者血浆 ET 含量均明显增高，差异有统计学意义（P0.01）；冠心病秽浊痰阻证组血 浆 ET 含量与非秽浊痰阻证组比较，差异亦有统计学意义（P0.05）；2）血浆 TM 含量的比较：与健康对照组相比，冠心病秽浊痰阻证组、非秽浊痰阻证组患者血浆 TM 含量增高，差异均有统计学意义（P0.01）；冠心病秽浊痰阻证组血浆 TM 含量 高于非秽浊痰阻证组（P0.05）。结论：冠心病秽浊痰阻证的实质是秽浊痰湿阻于 脉道，闭阻气血，而致痰瘀内生，微观表现是 ET、TM 水平升高，表明冠心病秽浊 痰阻证与非秽浊痰阻证相比，其血管内皮损伤更为明显。血浆 ET、TM 可以作为冠 心病秽浊痰阻证中医辨证的客观依据。 关键词：冠心病；秽浊痰阻证；血浆内皮素；血浆血栓调节蛋白； 新疆医科大学医学硕士学位论文 The Study on the relationship between endothelium dysfunction and the HuiZhuoTanZu Syndrome of Coronary Heart Disease Postgraduate:Fu Xiao-le Tutor: Pro. An Dong-qing Abstract Objective:The aim of this study is to investigate the plasma level of Endothelin(ET) and Thrombomodulin(TM), so as to explore the relationship between CHD HuiZhuoT- anzhu Syndrome and endothelium dysfunction, provide the microcosmic objective basis for working out the diagnose standard for the coronary heart disease HuiZhuoTanZu Syndrome, in order to make its diagnose tend being externalization. Methods: A total of 172 samples were obtained from 84 cases of CHD huizhuotanzu syndrome and 88 cases of CHD non-huizhuotanzu syndrome, 78 cases of normal controls, then observe and analyses the general data and the plasma level of ET、TM among three groups. Results: 1) Comparison of plasma ET: Compared with normal controls, the lever of ET of CHD HuiZhuoTanzhu Syndrome group and non-HuiZhuoTanzhu Syndrome group are significantly higher, the difference is statistically significant (P0.01 ); between CHD HuiZhuoTanzhu Syndrome group and the non- HuiZhuoTanzhu Syndrome group, there is a significant difference in the lever of ET (P0.05). 2) Plasma TM level in comparison: the lever of TM in CHD HuiZhuoTanzhu Syndrome group and non- HuiZhuoTanzhu Syndrome group are higher th