冠状动脉钙化相关标志物与钙化积分的相关性及临床诊断价值分析-临床检验诊断学专业论文.docxVIP

万方数据 万方数据 1,25(OH)2D3、HIF-1a、 IL-18、MGP、OPN5 个标志物血清浓度在不同钙化积分 组和对照组之间比较，差异有统计学意义，且这 5 个标志物与钙化积分由相关性， 这些标志物可作为诊断 CHD 的诊断指标。2. 各标志物联合应用，诊断性能良好， 其中以 HIF-1a、MGP、1,25(OH)2D3 三项联合检测可能实用价值更好。3.钙化积 分参数模型：LnP(积分)=-3.99+0.013*1,25(OH)2D3+0.096*HIF-1a+0.005*MGP， 此参数模型可作为评估钙化积分的一个参考工具，可作为双源 CT 冠脉成像检查 的一个补充和参考，同时节约医疗成本及避免有创检查。 【关键词】冠心病；心脏标志物；冠状动脉钙化；钙化积分；诊断价值 Study of the relevance and clinical diagnostic value of coronary artery calcification related markers and calcific integral Major: clinical laboratory diagnostics Postgraduate: zengqingna Supervisor: huangyunzhu and huangshan professor [Abstract] Objective: Investigated the relevance and clinical diagnostic value of coronary artery calcification cardiac related markers and calcific integral. Methods: The principle of evidence-based medicine would be used in estimated the literatures which be brought into and markers in the literatures. Used dual source CT to examine and calculate patients’ calcification integral. Detected the serum markers level of normal people and patients with different calcification integral coronary heart disease by ELISA method, and statistical analyze the result. Selected significant difference III markers to draw the ROC curve which used the application of statistical software. Through the area under ROC curve (AUC) to evaluate the effect of the diagnosis in joint detection of cardiac markers. The coronary artery calcification integral parameter model was established and that was evaluated. Results: Used the method of evidence-based medicine on 691 articles and 22 markers which was evaluated by statistical analysis. Finally, 52 articles were included. There were 9 biomarkers related with coronary artery calcification (IL-10 、 IL-18 、 PAPP-A 、 HMGB1、1,25(OH)2D3、APN、HIF-1a、MGP、OPN). After the serum levels of disease group and control group were detected. the serum levels of 1,25(OH)2D3、 HIF-1a、IL-18、MGP and OPN markers in two groups had statistical difference (p0.05). T