胍基丁胺对大鼠肺动脉张力的调节及受体机制的初步研究-病理生理学专业论文.docxVIP

第三军医大学硕士研究生论文 第三军医大学硕士研究生论文 PAGE PAGE 12 英文缩写一览表 英文缩写 ACH 英文全称 acetylcholine 中文全称 乙酰胆碱 ADC arginine decarboxylase 精氨酸脱羧酶 AGM agmatine 胍基丁胺 α2-AR α2-adrenergic receptor α2-肾上腺素能受体 L-Arg L-arginine 左旋精氨酸 CDS clonidine displacing substance 可乐定置换物质 COX cyclooxygenase 环氧合酶 HPH hypoxic pulmonary hypertension 缺氧性肺动脉高压 IR imidazoline receptor 咪唑啉受体 Gly glybenclamide 优降糖 LV left rentriclar weight 左心室重量 MPAP L-NAME mean pulmonary artery pressure Nω-nitro-L-Arginine nethyl ester 肺动脉平均压 Nω-硝基-L-精氨酸甲酯 NO nitric oxide 一氧化氮 NOS nitric oxide synthase 一氧化氮合酶 OD optical density 光密度 PASP pulmonary artery systolic pressure 肺动脉收缩压 PBS phosphate buffer saline 磷酸盐缓冲液 PE phenylephrine 苯肾上腺素 RV right ventricular weight 右心室重量 RVDP pulmonary artery diastolic pressure 肺动脉舒张压 SEP interventtricular septum 室间隔 TEA tetraethylammonium 四乙基铵 Primary study of regulation effects of agmatine on pulmonary artery tension and its receptor mechanisms in rats Abstract Li, et al separated a molecule from bovine brain cortex that could substitute clonidine and was approved as agmatine (AGM) in 1994. Agmatine is transformed by L-arginine in function of arginine decarboxylase. In recent years, researchers discovered that agmatine was extensively distributed in tissues of mammal. It major works on imidazoline receptors (IR), along with 2-adrenoceptor and can regulate certain neurotransmitter release. It has various biological activity such as decrease the blood pressure, reduce serum glucose excrete the urine antagonize the tolerance and the dependence of opioid agonists, all of these suggested that agmatine was a novel neurotransmitter or neuromodulator. However, the biological function, pathophysiological significance and mechanisms of agmatine still remain vague. Gao, et al( Life Science 1995) reported that agmatine is a novel endogenous vasoactive substances, which can cause arterial blood pressure in systemic hemodynamics and peripheral vascular resistance descent .The agmatine works in a way differ f