课件：呼吸系统疾病及其它细菌性疾病.ppt

App with pleuritis 胸膜肺炎放线杆菌感染的胸膜炎 2019 - * 2019 - * 2019 - * Treatment 治疗 Only Injectables 仅注射 Penicillin 青霉素 Many different forms 一些不同的剂型 10000 IU/lb 1000国际单位/磅 Test for susceptibility 药敏试验 Tiamulin泰妙菌素 Can be used orally 可以口服 Very good activity 药物活性很强 Spectinomycin 壮观霉素 Cephalosporin 头孢菌素 Excellent 效果非常好 Expensive 昂贵 2019 - * - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Respiratory disease - Actinobacillus pleuropneumonia呼吸道疾病－－胸膜肺炎放线杆菌  Bob Morrison DVM, MBA, PhD Swine Group University of Minnesota 2019 - * Etiology 病因学 Actinobacillus (“Haemophilus”) pleuropneumoniae (APP) 胸膜肺炎放线杆菌（“嗜血杆菌”） 15 Serotypes 15个血清型 Most common are 1, 5, 7 in the USA 在美国，血清型1、5、7最为常见 Serotype 12 is very common but apparently not virulent 血清型12也很常见，但是它不表现致病性 Serotypes 13-15 are proposed and probably not common 血清型13－15被提及，可能不是很常见 Differences in virulence between serotypes 血清型之间的毒力差别 Serotype prevalence may be changing due to vaccination 由于接种疫苗的原因，血清型的流行性可能会改变 2 biotypes – NAD dependent and independent (biotypes 1 and 2) 2个生物变种－依赖和不依赖烟酰胺腺嘌呤二核苷酸（生物变种1和2） Biotype 1 is more common, but 2 is increasing 生物变种1更普遍，但是生物变种2逐渐增加 2019 - * Virulence Factors毒力因子 Capsule 荚膜 LPS-endotoxin 脂多糖－内毒素 Exotoxin (Hemolysins/Cytotoxins) 外毒素（溶血素/细胞毒素） Outer Membrane Proteins (OMP) 外膜蛋白 （OMP） 2019 - * Clinical signs – Acute form临床症状－急性型 Epidemiology 流行病学 Susceptible herds--all animals are affected 易感猪群－所有的动物可被感染 Morbidity is very high 发病率非常高 Mortality usually is also high 死亡率通常也很高 The organism spreads without apparent relationship to any management factors 病原体的传播与任何管理因素没有明显的关系 Vaccines are very dramatic because they stop death 疫苗效果显著，因为其阻止了猪的死亡 Rather uncommon today, but may be seen in high-health herds 目前很不常见，但是可见于健康良好的猪群 Signs 症状 High fever 高热 Some coughing 有些咳嗽 Very labored breathing 严重 呼吸困难 Death 死亡 Nose ble