课件：与代谢异常相关的异子宫出血修改版.ppt

Weiwei Shan 等研究表明 代谢异常不仅与I型子宫内膜癌有关，还与子宫内膜增殖与子宫内膜增生有关 研究表明体质指数、高密度脂蛋白、空腹血糖和空腹胰岛素与子宫内膜增生性病变密切相关 胰岛素抵抗指数是子宫内膜增生性病变的独立危险因素 代谢异常广泛存在于子宫内膜增生性病变及子宫内膜增生紊乱中，代谢异常(代谢综合征）很可能是子宫内膜增生性病变发生的关键因素 Weiwei Shan a,b,1, Chengcheng Ning a,b,1, Xuezhen Luo Hyperinsulinemia is associated with endometrial hyperplasia and disordered proliferative endometrium: A prospective cross-sectional study 单伟伟，罗雪珍等 代谢异常与子宫内膜增生性病变的关系 - 王艳杰，陈晓军等研究表明血清脱氢表雄酮（DHEA）及胰岛素抵抗指数(HOMA-IR)联合检测能有效评估子宫内膜增生过长患者的病变程度 IatrakisG等研究表明血清胰岛素水平升高在子宫内膜增生过长病变中起重要作用 机制为直接刺激卵巢间质细胞生成雄激素过多,同时自身也能在酶的作用下转变为雌激素,并上调子宫内膜组织中的雌激素受体的密度 王艳杰，陈晓军 血清性激素及胰岛素水平与子宫内膜增生程度的相关分析 IatrakisG,Tsionis C,Polycystic ovarian syndrome ,insulin resistance and thickness of the endometrium[J]2006 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - 代谢紊乱与异常子宫出血 ````````````````````````````````````````````````````````````` ````````````````````````````````````````````````````````` - 主要内容 代谢异常的相关概念 01 胰岛素抵抗病因及相关疾病预防治疗 03 与胰岛素抵抗有关的异常子宫出血及相关研究 02 - 代谢紊乱 是身体的一种状态 是机体对物质的消化、吸收、排泄出现病理性、不协调 的供需不平衡的状态 可以表现为一种物质也可以表现为多种物质的紊乱 - 代谢紊乱类型 营养物质代谢紊乱：糖紊乱，脂肪紊乱，蛋白质代谢紊乱 代谢产物代谢紊乱：尿酸代谢紊乱 电解质代谢紊乱：高钾、 低钾，高氯、低氯 - 糖代谢紊乱： 高血糖症与糖尿病 低血糖症 酮症 半乳糖血症 - ``````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````````` - 什么是胰岛素抵抗与高胰岛素血症？ - 胰岛素抵抗是指各种原因使胰岛素促进葡萄糖摄取和利用的效率下降，机体代偿性的分泌过多胰岛素产生高胰岛素血症，以维持血糖的稳定。胰岛素抵抗易导致代谢综合征和2型糖尿病 全国糖尿病防治组测算的胰岛素抵抗指数HOMA-IR2.69判定为