LC-MS-MS测定烤鳗中4种氟喹诺酮药物残留量.PDF

23 5 Vol. 23 No. 5 2004 9 FENXI CESHI XUEBAO( Journal of Instrumental Analys s) 43~ 47 LC- MS- MS 4 林 峰, 林海丹, 吴映璇, 王 芳 ( , 510623) : LC- MS- MS , 4 , , 10~ 50 Lg/ kg , 10 Lg/ kg 4 , MS- MS- MS : - - ; ; : O657. 63; R978. 1 : A : 1004- 4957( 2004) 05- 0043- 05 Detect on of Four Fluoro u nolones n Processed Eels b L u d q y q Chromatography w th Tandem Mass Spectrometry LIN Fen , LIN Ha _dan, WU Y n _xuan, WANG Fan g g g ( Guangzhou Inspect on and Quarant ne Bureau, Guangzhou 5 10623, Ch na) Abstract: A l u d chromato ra h c method cou led w th tandem mass s ectrometr c detect on was deve-l q g p p p oped for the s multaneous analys s of four fluoroqu nolones res dues( norfloxac n, ofloxac n, c profloxac n and enrofloxac n) n processed eels( Pushao eels) . The res dues were extracted from sample by s mply so-l vent extract on. Good recover es were obta ned for four anal tes w th n 10~ 50 / k and the l m t of de- y Lg g tect on was found to be 10 / k . The method s also used for conf rmat on detect on. The effects of mo- Lg g b le hase and coll s on ener on the mass s ectrometr c behav or of fluoro u nolones are d scussed. The p gy p q uas - MS/ MS/ MS a roach was em lo ed for the eluc dat on of fra mentat on mechan sm of fluoro-