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课件:内分泌系统的病理生理学护理学.ppt
糖尿病的病理生理学 Disorder of metabolism (Carb, Prot Fat) Due to Absolute/relative deficiency of insulin. Characterized by hyperglycemia. Clinically : Polydipsia: excessive thirst. Polyphagia: excess hunger. Polyuria: increased urinary output. Summary of Diabetes ? Diabetes is a chronic illness that impacts on all aspects of life ? Treatment include insulin adjusting lifestyle ? People with diabets are responsble for this thus are the primary determinant of longer-term health ? The costs in human financial terms of poor control are great ? As self-care is paramount, psychological issues are foundamentally influential in current and long-term health Barriers to self-care Depression Stress and anxiety Fear of hypoglycaemia Lifestyle change 糖尿病的病理生理学 “The past cannot be changed, but the future can.. by actions in the present time.” --BK Past is history, Future is mystery Present is the gift…! Education and Monitoring Kapok-Bombax ceiba THANK YOU SUCCESS * * 可编辑 * Plasma free fatty acids might mediate the insulin resistance and impaired glucose tolerance associated with central obesity and type 2 diabetes. Visceral fat is more sensitive to lipolytic hormones than peripheral fat, and consequently results in increased release of FFAs into the portal system. Elevated portal FFAs might account for overproduction of liver glucose output with visceral adiposity. In additionally, portal FFA might reduce hepatic extraction of insulin, diminishing the necessity of increased beta-cell response to compensate for FFA-driven insulin resistance. Skeletal muscle accounts for the majority of whole-body glucose uptake, and insulin resistance is associated with reduced nonoxidative skeletal muscle glucose metabolism. In obese insulin-resistant individuals, this reduced metabolism may result from alterations in skeletal muscle fiber composition, post-insulin receptor signaling defects, or diminished microcirculatory blood flow, with consequent reduced delivery of insulin and gluco
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