英文课件激素在溃疡性结肠炎的应用PPT.ppt

此ppt下载后可自行编辑 The Clinical Application of Corticosteroids in Ulcerative Colitis Two parts The introduction of Ulcerative colitis The clinical application of Corticosteroids in Ulcerative colitis Ulcerative colitis Definition: Chronic non-specific colitis Inflammation of the mucosa and submucosa of the large intestine Features: diarrhea with feces containing mucus, pus and blood, abdominal pain and tenesmus; and recurrence is common Mostly seen in 20-50 years of age, and in Europe Less common in China Infection Environmental factors Genetic susceptible Immune inflammatory system Etiology and pathogenesis Location: rectum and sigmoid colon, then descending, transverse or pan-colon, even terminal ileum Mucosa diffused inflammation with edema, congestion and local bleedings. Pathology Infiltration of lymphocytes, plasma cells, eosinophilic cells and neutrophilic cells in mucosa Cryptic abscess and superficial ulcers Inflammatory polyps or pseudopolyps; UC UC Cryptic abscess in UC Clinical Manifestations Symptoms: diarrhea abdominal pain, others : tenesmus, anorexia, nausea and vomiting Signs: tenderness in the left hypogastrium and rebound tenderness Manifestations of digestive system Systemic manifestations fever,tachycardia,Anemia, malnutrition, volume depletion, disturbance in acid-basebalance and hypoalbuminemia in advanced patients Extra-intestinal manifestations erythema nodosum, arthritis, ankylosing spondylitis, iritis，episcleritis, conjunctivitis, ulcers of oral mucosa, chronic active hepatitis and so on. erythema nodosum A.course classification initial type chronic relapse type chronic permanent type acute and fulminant type Clinical classification UC B.Extent classification (1) mild type (2) moderate type (3)severe type Classification UC C.range classification Proctitis or proctosigmoiditis:40-50% Left-sided or intermediate colitis :3