达英-35联合二甲双胍治疗多囊卵巢综合症的临床疗效研究.doc

达英-35联合二甲双胍治疗多囊卵巢综合症的临床疗效研究 孙芙蓉 （ 中铁一局集团中心医院妇产科 陕西省华县 714100 ） 摘要 目的：探讨达英-35与二甲双胍合用治疗多囊卵巢综合症(polycystic ovary syndrome，PCOS)的临床效果。方法：选取我院2011年06月～2015年03月收治的37例多囊卵巢综合症患者作为研究对象，将其随机分为达英-35组11例、二甲双胍组14例和联合用药组12例，观察记录并比较总结三组患治疗前后的临床症状和相关指标。结果：达英-35组患者血清LH、FSH、LH /FSH和睾酮与治疗前下降显著，差异具有统计学意义（P0.05 ）；而F-Ins、LDL-C、HDL-C、总胆固醇、甘油三酯与治疗前变化不大，差异无统计学意义（P0.05）；二甲双胍组治疗后患者的血清F-Ins、LDL-C、HDL-C和甘油三酯含量明显优于治疗前，差异具有统计学意义（P0.05），而LH、FSH、LH /FSH、睾酮和总胆固醇与治疗前相比差异无统计学意义（P0.05）；而联合用药组患者血清各项指标均有统计学差异（P0.05）。结论：达英-35与二甲双胍联合应用，能相互弥补各自的不足、增强效果，在多囊卵巢综合症的治疗中疗效显著，值得临床广泛推广应用。 多囊卵巢综合症(polycystic ovary syndrome，PCOS)是一种内分泌紊乱综合征，高雄激素血症及胰岛素抵抗为其两大主要病理生理机制 ADDIN EN.CITE EndNoteCiteAuthorTaghavi/AuthorYear2015/YearRecNum160/RecNumDisplayText[1]/DisplayTextrecordrec-number160/rec-numberforeign-keyskey app=EN db-id=av0xx5wvq5rd0betfrjvtreza2sws20es2ss160/key/foreign-keysref-type name=Journal Article17/ref-typecontributorsauthorsauthorTaghavi, S. A./authorauthorBazarganipour, F./authorauthorMontazeri, A./authorauthorKazemnejad, A./authorauthorChaman, R./authorauthorKhosravi, A./author/authors/contributorsauth-addressMother and Child Welfare Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.#xD;Mental Health Research Group, Health Metrics Research Center, Iranian Institute for Health Sciences Research, ACECR, Tehran, Iran.#xD;Department of Biostatistics, Tarbiat Modares University, Tehran, Iran.#xD;Department of Social Medicine, School of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran.#xD;Center for Health Related Social and Behavioral Sciences Research, Shahroud University of Medical Sciences, Shahroud, Iran./auth-addresstitlestitleHealth-related quality of life in polycystic ovary syndrome patients: A systematic review/titlesecondary-titleIran J Reprod Med/secondary-titlealt-titleIranian journal of reproductive medicine/alt-title/titlesperiodicalfull-titleIran J Reprod Med/full-titleabbr-1Iranian journal of reproductive medicine/abbr-1/periodicalalt-periodicalfull-