邻苯二甲酸二异辛酯对小鼠不同脏器ATPase活性的影响及其机制的研究-生物化学与分子生物学专业论文.docxVIP

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邻苯二甲酸二异辛酯对小鼠不同脏器ATPase活性的影响及其机制的研究-生物化学与分子生物学专业论文.docx

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⑨ ⑨ 硕士学位论文 MASTER’STHESIS Abstract ATP could supply energy for life activity．And the mitochondrion is ubiquity in the cytoplasm of eukaryotic cell，which is of being sensitive tO organ injury．ATPase could hydrolyze ATP to supply activity．So ATP and ATPase are of great importance in the course ofmetabolism．At present．many reports about the toxicity ofDEHP have been reported at home and abroad．．nle study even goes deeD into the level of molecule．The reports about effects of Di一2一ethylhexyl Phalate and activity of ATPase in mice have not been reported，SO this studY is important to the biotoxicity study ofDEHP． To find out the the effect of Di．2．ethylhexyl Phalate about activity of ATPase in the mitochondrion and viscera cell of mice，the livers，hearts，kidneys，cerebrums and testicles of Kunming mice were applied in this study．and the activity ofATPase was measured through mensurating inorganic phosphorus based on the follow mechanism： ATP酶 With the increase of the dosage of DEHP．the activity of Na十一K+--ATPase and Cr—Mg”--ATPase in livers、cerebrums and testicles descend at first．and then ascend． the activity in liver reach the lowest activity at the dosage of DEHP 200mg．k91．d‘，and the activity in cerebrums and testicles reach the lowest activity at the dosage of DEHP 100 mg．k岔1．d-1．but，In hearts and kidneys，the activity ofNa+一K+--ATPase and Ca2+一 M一+--ATPase ascend at first，and then descend．The activity of Nat—K+--ATPase reach the highest activity at the dosage ofDEHP 200rag．kg-1．d一，and the activity ofCa2+ 一M∥+--ATPase reach thc higlIest activity at the dosage ofDEHP 300mg．kg．d-1．wjm the increase ofthe dosage ofDE肿，the activity ofNa十一K+一ATPase and Ca”一M∥+ 一ArPase in the mitochondrion of livers and hearts descend． As shown in figure l and figure 2．the influence by DEHP on the activity of Na+．K+一ATPase and Ca2+．M92+．ATPase ofthe same orgall iU mice had similar trend．But the inflaence by DEHP on the same ATPase of the different organs in mice did not have similar trend．This