(原版)栓剂在临床应用中新进展.docVIP

栓剂在临床应用中的新进展 摘要 随着近些年来栓剂剂型的不断发展，药学自身的研究不断完善，以及患者对药物安全性，稳定性以及治疗需求不断提高，栓剂的研究与发展也迎来了一次新热潮。新型栓剂质量的提高和改善成为栓剂发展的重点和方向。 普通栓剂在用药过程中的血药浓度不稳定，容易潮解，氧化和变质。为了适应临床的需要，新型栓剂提高了生物利用度，并且具备了明显的缓释特征，有良好的稳定作用，较普通栓剂有了明显的优势。新型药用辅料和制备技术也渗透到了栓剂的制备当中。研究栓剂在临床治疗中的新进展，成为了药学工作者不可或缺的工作，对于栓剂的发展有着十分重大的意义。 关键词：新型栓剂；临床治疗；栓剂进展；生物利用度；首过效应。 Suppositories New Progress In Clinical Application Author: Zhang Ya Nan 　　　 Tutror: Chen Hong Xuan Abstract With the continuous development of suppositories dosage forms in recent years, the pharmaceutical research constantly improve itself, and patients in drug safety, stability and treatment needs to improve, the research and development of the suppositories also ushered in a new boom. To promote the quality of new type suppository and improve become the focus and direction of the development of suppositories. Common suppositories in blood drug concentration in the process of drug use is not stable, easy deliquescence, oxidation and deterioration. In order to meet the needs of the clinical, new suppository can improve the bioavailability, and had the obvious sustained release characteristics of good stability, the ordinary suppository has obvious advantages. New types of medicinal materials and preparation technology is penetrating into the preparation of suppository. Research suppository on new progress in the clinical treatment, has become the indispensable to pharmaceutical workers work, has a very significant for the development of the suppositories. Key words: New suppository; Clinical treatment; Suppositories progress; Bioavailability; First an effect 目 录 1栓剂的应用 1 1.1栓剂的应用概况与研究进展 1 1.2栓剂的作用特点 1 1.2.1局部作用 1 1.2.2全身作用 1 2新型栓剂 2 2.1中空栓剂 2 2.1.1糊精包合物中空栓 2 2.1.2自乳化中空栓 3 2.1.3固状离散型空心栓状物 3 2.1.4中空泡腾栓 4 2.2微囊栓剂 4 2.3 两层栓状药剂 5 2.4中药栓剂 6 2.4.1肛门中药栓 6 2.4.2阴道中药栓 7 3结 语 8 致谢 9 参考文献 10 1.栓剂的应用 栓剂是药物与适宜的机制混合后制成专供不同腔道给药的一种固体的制剂。 1.1栓剂的应用概况与研究进展 在我国，栓剂有着非常悠久的历史，古时又称为坐药