囊性纤维变性跨膜调节器基因突变对男性生殖的影响.pdf

170 Chinese Journal of Pathophysiology 2001, 17(2) : 170- 173 [ ] 1000- 4718(2001) 02- 0170- 04 1 2 3 4 周晨曦, 王 曦, 王子栋, 黄宜定 1 2 ( , 510260; , 3 , 510632; 4 ) Effect of cystic fibrosis transmembrane conductance regulator gene mutation on male fertility 1 2 3 4 ZHOU Chen- xi , WANG Xi , WANG Zi- ong , PYD Wong 1 ( Guangdong Entomological Institute, Guangzhou 510260, China; 2 Institutef or Tissue Transplantation Immunology, Jinan University, Guangzhou 510632, China; 3 epartment fo Physiology, Medical College of Jinan University, Guangzhou 510632, China; 4 epartment of Physiology, The Chinese University fo Hong Kong, China) [A Review] Large number of cystic fibrosis transmembrane con uctance regulator ( CFTR) gene muta tions are responsible for a wi e spectrum of isease expressions in CF ( cystic fibrosis) . They inclu s not only the malfunction of the lung an pancreas, intestinal obstruction, an incapable of salt reabsorption, but also some kin s of male infertility, such as congenital bilateral absence of the vas eferens ( CBAVD) , poor sperm quality, the obstruction an agenesis of the epi i ymis. More recent stu ies have in icate that CFTR gene mutations have a far- reaching effect on human repro uction. [ ] ; ; [MeSH] Cystic fibrosis; Fertility; Epi i ymis [ ] R339. 2 [ ] A 1 CFTR CFTR cAMP , ( cystic fibrosis trans -