IL-27、RANKL在类风湿关节炎中的变化及其对骨质疏松的影响.pdf

山西医科大学硕士学位论文 2. RA 患者血清中IL-27 、RANKL 水平及IL-27/RANKL 比值均明显升高，但与疾病 活动性指标均无相关性，提示两者并不能反映疾病活动性；3. IL-27 可能通过某种机 制影响RA 的骨代谢，具体机制有待进一步研究。 关键词： 类风湿关节；IL-27 ；RANKL；骨密度；骨质疏松 II 山西医科大学硕士学位论文 Change of IL-27 、RANKL in patients with rheumatoid arthritis and its influence on osteoporosis Abstract Objective: Through testing serum levels of interleukin (IL - 27) and nuclear factor kappa B receptor activation factors predominate the change of the ligand (RANKL) of patients with rheumatoid arthritis (RA) and normal group, research the relationships with disease activity, and preliminary discussion their effects on osteoporosis in patients with RA. Methods: The first hospital of shanxi medical university for the first time of 55 patients with diagnosed with RA, consistent with 2010 ACR/EULAR classification criteria of RA. Patients without using any immunosuppressant and taking hormone, there is no history of anticoagulant and affect bone metabolism of drugs, without severe renal damage, thyroid, parathyroid disease. 42 patients age and gender matched normal persons as control group, its early in the morning on an empty stomach blood collection, save the serum and separation. Were measured by ELISA method in 55 patients with RA and 42 cases of normal serum IL - 27 and RANKL levels, Use the calcaneus ultrasonic bone mineral instrument measurement test bone mineral density. And then analysis RA patients serum IL - 27, RANKL levels and both its relationship with disease activity index, and analyzes the relationship with osteoporosis. Results: 1. The RA group of bone mineral density significantly lower than normal group (P