脂肪营养不良综合征.pptVIP

Diagnosis 1.caliper measurements卡尺测量 of skinfold thickness皮肤褶皱厚度 may be helpful to quantify or characterize fat loss. Approximately 90% of adult men and women will have skinfold thickness values ≥10 mm and ≥22 mm; lower thickness values are supportive information for the diagnosis of lipodystrophy. 2.When fat loss is not visibly evident by physical manifestations, hyperglycemia高血糖 and hypertriglyceridemia高甘油三脂血症 that are resistant or unresponsive to conventional treatment may serve as the only indication to the clinician that a patient may have lipodystrophy. Diagnosis 3.Lipodystrophy is typically accompanied by low (or relatively low) levels of the adipocyte-secreted hormone leptin. leptin levels may provide useful supportive information, but are not necessary or specific for the diagnosis of lipodystrophy, as low leptin levels may be observed in other conditions (e.g., hypothalamic amenorrhea下丘脑性闭经and malnutrition). 4.lipodystrophy may also present with associated neuroendocrine神经内分泌 and immunological abnormalities免疫异常 (e.g., amenorrhea and a relative deficiency of T lymphocyte populationsT淋巴细胞缺乏) Therapies 1. lifestyle modifications (diet and exercise) 2.conventional antihyperglycemic and lipid-lowering edications Metformin二甲双胍, sulfonylureas磺脲类, thiazolidinediones噻唑烷二酮, and insulin can be used to manage hyperglycemia, while fibrates贝特类 and statins他汀类 can be used to manage hypertriglyceridemia. Where metabolic abnormalities代谢异常 associated with lipodystrophy are particularly severe, conventional treatments, alone or in combination, are likely to be inadequate at re-establishing metabolic control. Lipodystrophy syndromes definition and classification Clinical Findings of the Major Lipodystrophy Subtypes Clinical Characteristics structure Diagnosis Therapies definition and Classification A heterogeneous group of congenital or acquired disorders characterized by either complete or partial lack of adipose tissue ，which may occu