血栓性血小板减少性紫癜及其他血栓性微血管疾病的诊断和治疗指南(英文).pdf

guideline Guidelines on the diagnosis and management of thrombotic thrombocytopenic purpura and other thrombotic microangiopathies Marie Scully,1 Beverley J. Hunt,2 Sylvia Benjamin,3 Ri Liesner,4 Peter Rose,5 Flora Peyvandi,6 Betty Cheung,7 Samuel J. Machin8 and on behalf of British Committee for Standards in Haematology 1Department of Haematology, UCLH, London, 2Department of Haematology, King’s College and Guys St Thomas’ NHS Trust, Lon- don, 3Department of Haematology, NBSBT and Oxford University Hospitals (OUH) Trust, UK, 4Department of Haematology, GOSH, London, 5Department of Haematology, University Hospitals Coventry Warwickshire NHS trust, Coventry, UK, 6Department of Haematology, IRCCS Maggiore Hospital Ca’ Granda Foundation, University of Milan, Milan, Italy, 7Department of Haematology, Queen Elizabeth Hospital, SLHT, London and 8Department of Haematology, UCL, London, UK n c . Keywords: thrombotic thrombocytopenic purpura, the regional UK registry occurred within 24 h of presenta- e thrombotic microangiopathy, guidelines. tion, primarily in women (Scully et al, 2008). In the last 15 years there has been a marked increase in v The guideline group was selected to be representative of UK- the understanding of the pathogenesis of TTP. It is now based medical experts. MEDLINE and EMBASE were recognized that congenital and acute acquired TTP are due