Combination of metformin with chemotherapeutic drugs via different molecular mechanisms 不同分子机制的二甲双胍与化疗药物联合应用.pdf

Cancer Treatment Reviews 54 (2017) 24–33 Contents lists available at ScienceDirect Cancer Treatment Reviews journal homepage: /journals/ctrv Anti-Tumour Treatment Combination of metformin with chemotherapeutic drugs via different molecular mechanisms Mei Peng a,b,c,⇑, Kwame Oteng Darko b,c, Ting Tao b,c, Yanjun Huang b,c, Qiongli Su b,c, Caimei He b,c, Tao Yin a, Zhaoqian Liu a, Xiaoping Yang b,c,⇑ a Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China b Department of Pharmacy, School of Medicine, Hunan Normal University, Changsha, Hunan 410013, China c Animal Nutrition and Human Health Laboratory, Hunan Normal University, Changsha, Hunan 410013, China a r t i c l e i n f o a b s t r a c t Article history: Metformin, a widely prescribed drug for treating type II diabetes, is one of the most extensively recog- Received 9 December 2016 nized metabolic modulators which has shown an important anti-cancer property. However, fairly Received in revised form 9 January 2017 amount of clinical trials on its single administration have not demonstrated a convincing efficiency Accepted 11 January 2017 yet. Thus, recent studies tend to combine metformin with clinical commonly used chemotherapeutic drugs to decrease their toxicity and attenuate their tumor resistance. These strategies have displayed promising clinical benefits. Interest