艾贝宁在小儿麻醉领域的应用.ppt

右美神经保护作用研究 * Dexmedetomidine provides neuroprotection: impact on ketamine-induced neuroapoptosis in the developing rat brain. AbstractKetamine and dexmedetomidine are increasingly used in combination in pediatric patients. This study examined the hypothesis that dexmedetomidine attenuated ketamine-induced neurotoxicity. Neonatal rats were randomly divided into four groups (n=10, male 5, female 5). Group S+S 腹腔内注射等量生理盐水+5分钟后皮下注射等量生理盐水 Group K+S 腹腔内注射75mg/kg氯胺酮+5分钟后皮下注射等量生理盐水 Group S+D 腹腔内注射等量生理盐水+5分钟后皮下注射25ug/kg右美托咪定 Group K+D 腹腔内注射75mg/kg氯胺酮+5分钟后皮下注射25ug/kg右美托咪定 右美神经保护：对氯胺酮在发育的幼鼠脑部造成神经损伤的影响 Acta Anaesthesiol Scand 2014 Oct;58 (9): 1121-6. 结论5：右美对脑神经具保护作用 * Neuronal apoptosis in the CA1 region and the dentate gyrus of rats was examined by transferase dUTP nick end labeling (TUNEL) assays. Learning and memory abilities of 2-month old rats were examined by Morris water maze test. The results were analyzed by analysis of variance. The percentage of TUNEL-positive cells in group K+S (CA1, 49.0±9.46 and dentate gyrus, 49.4±5.41) was markedly higher than that in group K+D (CA1, 37.2±5.54 and dentate gyrus, 35.2±5.06) (F=5.49, P0.05 and F=13.51, P0.001, respectively). Group K+S took significantly longer time and swimming distance to find the hidden platform on the fourth and fifth training days than group K+D (P0.05). 幼鼠大脑海马CA1区和齿状回区神经细胞损伤通过TUNEL监测，2个月大幼鼠学习和记忆能力通过水迷宫试验检测。Group K+S组TUENL显示阳性（即CA1值为49.0±9.46 ，齿状回区值 为49.4±5.41） 且显著高于Group K+D (CA1-37.2±5.54 ， 齿状回区值35.2±5.06）。 Group K+S组比GroupK+D组花费更长时间和游泳距离去寻找隐藏的平台。 In conclusion, ketamine caused neuroapoptosis and impaired brain functions in the developing rat brain which can be effectively attenuated by dexmedetomidine. Dexmedetomidine alone was not neurotoxic to the developing brain. 结论，氯胺酮引起的幼鼠脑神经损伤可被右美托咪定有效减弱；右美托咪定单独使用时对发育期幼鼠无神经毒性。 Acta Anaesthesiol Scand 2014 Oct;58 (9): 1121-6. 右美用于小儿术后镇痛临床效果 不同剂量右美托咪定复合吗啡硬膜外镇痛对小儿尿道下裂术后镇痛效果的影响 * C组 罗哌卡因100ug+吗啡2mg+生理盐水至100ml D1组 罗哌卡因100mg+吗啡2mg+右美托咪定0.2ug/kg+生理盐水至100ml D2组 罗哌卡因100mg