血糖及糖化血红蛋白的检测及干扰研究进展-医学信息.pdf

学信息2019 年3 月第32 卷第5 期 Medical Information Mar. 2019 Vol. 32 No.5 综述 血糖及糖化 红蛋白的检测及干扰研究进展 李亮亮 王伟灵 赵 诚 尹 元 渊上海中医药大学附属上海市中西医结合医院检验科 上海 200082冤 摘要 2010 年美国糖尿病协会将糖化血红蛋白渊HbA1c冤检测作为筛选和诊断糖尿病指标 其参考界值为HbA1c 6.5%遥 至此 HbA1c 同血糖一样正式成为糖尿病诊断检测指标遥 血糖及HbA1c 作为杰出的糖尿病诊疗指标 其检验方法灵活多变且较易受 外界多种因素影响 干扰检测结果的准确性遥 随着检验技术的进步 床与糖尿病诊疗相关的生物传感器的应用逐渐广泛 本 文将针对二者常见检测方法的干扰因素做一综述遥 关键词 糖尿病曰血糖曰糖化血红蛋白 中图分类号 R587.1 文献标识码 A DOI:10.3969/j .issn.1006-1959.2019.05.015 文章编号 1006-1959渊2019冤05-0043-05 Progress in Detection and Interference of Blood Glucose and Glycated Hemoglobin LI Liang-liang,WANG Wei-ling,ZHAO Cheng,YIN Yuan (Department of Clinical Laboratory,Shanghai Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine,Shanghai 200082,China) Abstract ：In 2010, the American Diabetes Association used glycosylated hemoglobin (HbA1c) as a screening and diagnostic diabetes indicator with a reference margin of HbA1c 6.5% . At this point, HbA1c has officially become a diagnostic indicator for diabetes, j ust like blood sugar. Blood glucose and HbA1c are excellent indicators for diagnosis and treatment of diabetes. The test methods are flexible and changeable, and are more susceptible to various external factors, which interferes with the accuracy of test results. With the advancement of testing technology, the application of biosensors related to clinical diagnosis and treatment of diabetes has become more and more extensive. This paper will review the interference factors of common detection methods. Key words ：Diabetes;Blood sugar;Glycated hemoglobin 糖尿病（diabete ）是以高血糖为主要特 的内分 群的循证证据，以及临床应用的适用性和实用价值， 泌代谢性疾病[1] ，研究表明其发病率逐年升高，我国 依据必威体育精装版研究证据经过数次修订，更加明