肺脏的水孔蛋白家族-北京大学学报.pdf

中国病理生理杂志 　Chinese Journal of Pathophysiology 　2001 ,17 ( 11) :1089 - 1092 ·1089 · ( ) [文章编号] 　1000 - 4718 2001 11 - 1089 - 04 ·综 　述 · 肺脏的水孔蛋白家族 1 1 2 陈　　彧 , 　王京生 , 　李学军 (1北京大学人民医院心外科 ,北京 100044 ; 2 北京大学医学部基础医学院药理教研室 ,北京 100083) Aquaporins in lung CHEN Yu1 , WAN GJingsheng1 , L I Xuej un2 (1 Dep artment of Cardiovascular S urgery , Peking University Peop le ’s Hosp ital , B eij ing 100044 ; 2 ) 　 Dep artment of Pharmacology , Peking University Health Centre , B eij ing 100083 　　[ A Revie w] 　Aquaporins (AQPs) is a novel family of membrane protein which is in charge of the trans portation of water across the membranes. It has been testified that AQPs may be related to many physiological functions and pathophysiological disorders. In lung , 6 subtypes of AQPs were found , 4 of which have been lo cated in certain tissue . AQP1 , AQP3 , AQP4 and AQP5 are located in upper respiratory tract and may con tribute to the mucus production , bronchial moisturizing and gland secretion . AQP1 and AQP5 are located in lower respiratory tract and may participate in directing the water movement across the blood - gas barrier . AQPs in natal lung may be an important factor to accelerate the reabsorption of the lung liquid . In adult , some diseases such as asthma , pulmonary edema , adult respiratory distress syndrome , which have been considered unbalanced water movement , may be also concerned with AQPs. The relationship between lung edema an