单羰基姜黄素类似物对Ⅱ型糖尿病大鼠非酒精性脂肪肝治疗作用探究.docx

单疑基姜黄素类似物对II型糖尿病大鼠非 酒精性脂肪肝治疗作用探究 摘要［目的］研究单疑基姜黄素类似物（代号B06） 对II型糖尿病大鼠非酒精性脂肪肝糖脂代谢紊乱的影响。 ［方法］应用高糖高脂饲料喂养，小剂量STZ干扰建立II型糖 尿病大鼠模型［1］,并随机分模型组、A75治疗组、C66治疗 组、正常对照组，各组均灌胃治疗12周；检测各组大鼠血 生化指标［2］。［结果］单疑基姜黄素类似物能明显改善试验 性II型糖尿病大鼠的血糖升高，FINS明显低于模型组；肝脏 TC、血清TG、TC有明显的降低作用，对血清HDL有明显的 升高作用，有统计学意义；［结论］单炭基姜黄素类似物对II 型糖尿病大鼠非酒精性脂肪肝有一定的治疗作用。 关键词单疑基姜黄素；II型糖尿病；非酒精性脂肪肝; 链月尿佐菌素；治疗作用 中图分类号R587. 1文献标识码A文章编号 1007-5739 (2014) 05-0276-03 Effect of Single Carbonyl Curcumin Analogues on Nonalcoholic Fatty Liver Disease in Type II Diabetic Rats HOU Jie 1 LIAO Min 2 YE Xian-cai 1 SHEN Zhong-fei (1 Teaching and Research Section of Anatomy, College of Medicine，Jia.xing University，Jiaxing Zhejiang 314001； 2 Teaching and Research Section of Anatomy and Embryology, Wenzhou Medical University) Abstract [Objective] To research the effect of single carbonyl curcumin analogues on nonalcoholic fatty liver disease in Type II diabetic rats?[Method]Bu订ding the Type II diabetic rats model that implicating with small dose of streptozotocin by raising heat breeding, randomly divided into model group, A75 treatment group, C66 treatment group, and normal control group, each rat was accordingly given lavage treatment for 12 weeks； then tested groups of sugar and lipid metabolism of blood biochemical indexes ?[Resu It s] In sugar meta bo lism, single hydroxyl curcumin analogues could obviously improve the experimental Type II diabetic rats blood glucose, FINS significantly lower than the model group? In lipid metabolism, liver TC, serum TG and TC were signif icantly lower, serum HDL significantly increased, and it had statistical significance?[Conclusion]Single hydroxyl curcumin analogues for Type II diabetes mellitus rats had a certain therapeutic effect of nonalcoholic fatty liver disease? Key words single hydroxyl of curcumin； Type II diabetes mellitus； nonalcoholic fatty liver disease； streptozotocin； therapeutic effect II型糖尿病是由于体内胰岛素相对不足或靶细胞对胰 岛素敏感性降低所引起的内分泌代谢紊乱类疾病。调节糖皮 质激素水平的关键酶11 B-軽笛脱氢酶（11B-HSD）是催化 糖皮质激素合成和转化的关键酶，直接控制着