H3K27甲基化与EZH2在B细胞非霍奇金淋巴瘤中表观遗传调控的研究进展.PDF

1262 2015 42 12  Cancer Res Prev Treat,2015,Vol.42,No.12 · · 肿瘤防治研究 年第 卷第 期 doi:10.3971/j.issn.1000-8578.2015.12.020 ·综  述· H3K27 甲基化与EZH2 在 B 细胞非霍奇金 淋巴瘤中表观遗传调控的研究进展 1 2 2 3 邓玉洁 ，朱伟峰，陈刚，陈君敏 Progress of Epigenetic Regulation of H3K27me3 and EZH2 in B-cell Non-Hodgkins Lymphoma DENG Yujie1 2 2 3 , ZHU Weifeng , CHEN Gang , CHEN Junmin 1. Department of Chemotherapy, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China; 2. Department of Pathology, Fujian Provincial Cancer Hospital, Teaching Hospital of Fujian Medical University, Fuzhou 350014, China; 3. Department of Hematology and Rheumatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China Corresponding Author: CHEN Junmin, E-mail: drjunminchen@ Abstract: Aberrant modification of histone and DNA methylation are important fields in epigenetic research. Interaction between them often results in the activation or inhibition of specific genes. Methylation level of histone H3 lysine 27 and its methyltransferase EZH2 are closely correlated with specific classification of B-cell non-Hodgkins lymphoma (B-cell NHL) and its prognosis. This paper emphatically introduces the roles that H3K27me3 and EZH2 might play in the onset and development of B-cell NHL, and the possible mechanism as well. Key words: B-cell non-Hodgkin’s lymphoma; H3K27me3; EZH2; DNA methylation 摘  要：异常的组蛋白修饰与DNA 甲基化是表观遗传学研究的重要领域，两者相互作用可导致特 H3K27 EZH2 B 定基因的转录激活或抑制。 的甲基化水平及其甲基转移酶 可能与 细胞非霍奇金淋巴瘤 B-cell NHL H3K27me3 EZH2 B （ ）的特殊分型及不良预后密切相关。本文着重介绍 与 在 细胞非霍奇金 淋巴瘤中的发生和发展过程的作用及相应机制。 B H3K27me3 EZH2 DNA 关键词： 细胞