妇产科课件-子宫内膜癌英文.ppt

Endometrial Cancer OB/GYN Hospital Fudan University Xin LU, MD, Ph.D. Endometriod cancer---Contents Incidence Risk factors Classification Symptoms Pathology FIGO Staging Diagnosis Treatment WHO Cancer Report Global cancer rates could increase by 50% to 15 million by 2020 Endometrial cancer is the 4th most common cancer in women New Diagnosed cases: 142,000 Died cases each year: 42,000 incidence ~2-3% Average age: 60s Histologic Types Endometrial Cancers Endometrioid (87%) Adenosquamous (4%) Papillary Serous (3%) Clear Cell (2%) Mucinous (1%) Other (3%) Endometrial Cancer:Type I/II Type I Estrogen Related Younger and heavier patients Low grade Background of Hyperplasia Perimenopausal Exogenous estrogen Familial/genetic (~15% ) Lynch II syndrome/HNPCC Familial trend Type II (~10% ) Aggressive High grade Unfavorable Histology Unrelated to estrogen stimulation Occurs in older thinner women Endometrial Cancer: Risk Factors Endometrium Carcinoma2009 Classification Stage Characteristic Stage I* Tumor confined to the corpus uteri IA* No or less than half myometrial invasion IB* Invasion equal to or more than half of the myometrium Stage II* Tumor invades cervical stroma, but does not extend beyond the uterus** Stage III* Local and/or regional spread of the tumor IIIA* Tumor invades the serosa of the corpus uteri and/or adnexae# IIIB* Vaginal and/or parametrial involvement# IIIC* Metastases to pelvic and/or para-aortic lymph nodes#. IIIC1* ? Positive pelvic nodes IIIC2* ? Positive paraaortic lymphnodes with or without positive pelvic lymph nodes Stage IV* Tumor invades bladder and/or bowel mucosa, and/or distant metastases IVA*