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18 5 Vol. 18, No. 5
2006 10 Chinese Bulletin of Life Sciences Oct., 2006
1004-0374(2006)05-0437-05
2 1 0 0 6 3
20
10~20
Q959.837.03; Q95-33A
Genetic research of mouse
LIN Zhao-Yu, GAO Xiang*
(Model Animal Research Center of Nanjing University, Nanjing 210063, China)
Abstract: The history of mouse genetics started when mice strains were imported from pet farm to Castle’s
laboratory in Harvard University about one hundred years ago. Mouse genome is highly homologous to
human and can be modified by various approaches. Moreover, thousands of inbred strains , mutant strains and
“tool” strains have been developed. Therefore, mouse has become the key model animal for the research of
development biology, functional genomics and disease mechanism. Now the mouse genome project was
completed. Millions of microsatellite markers and SNPs among different inbred mouse strains were identified.
The assays for the physiology and biochemistry phenotypes are constantly improving, along with the collec-
tion of more and more data. These works enable the several programs for large scale genome mutagenesis, gene
targeting, as well as constructing and analyzing new recombined inbred strains. These programs may become
the most important studies in the biology and medicine resear
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