2014肺动脉高压的诊治进展.ppt

Erasmus University Rotterdam-thymic reticulum antibody-7 (ER-TR7)1 conduits formed by reticular fibroblasts and by expanded perivascular lymphatic elements Western blotting of IgG with protein extracts of human umbilical vein endothelial cells (HUVEC). Serum IgG from patients with IPAH, SSc-PAH, limited cutaneous SSc without PAH, and age and sex matched healthy controls was immunoblotted at 200 mg/ml with a soluble extract of HUVEC. Normal human polyclonal IgG (intravenous immunoglobulins) and secondary anti-Fcc antibody tested alone were used as positive and negative controls, respectively. Dexamethasone reverses monocrotalineinduced pulmonary arterial hypertension in rats MCP-1基因突变子7ND MTD 混合性结缔组织病 Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2014; 1843,885–893 总 结 现今靶向血管舒张的药物治疗PAH已取得一定疗效，但无法阻断疾病进展 未来治疗PAH药物应具有抗增殖和促进凋亡等改善肺血管重构效应 抗肿瘤药物在治疗PAH中可能对血管重构效应显著 miRNA，代谢调节和基因疗法具有应用前景 具有作用不同细胞，调节多种靶点的化合可能是最佳的抗PAH候选药物 知识回顾Knowledge Review * 目前大多采用2003年威尼斯WHO肺动脉高压专题会议对肺高压的诊断分类原则，废弃使用“原发性肺动脉高压、无法解释的肺动脉高压和继发性肺动脉高压”的诊断名词 * 由于误诊可能导致相应的治疗产生完全相反的效果，因此这个诊断分类至关重要 * 病因涉及多个学科，容易漏诊、误诊 * 肺动脉高压知晓率、确诊率和治疗率均很低 * Correlation of atrial natriuretic peptide (ANP) with baseline hemodynamic parameters. Open circles = patients with PPH; closed circles = patients with NPPH. Atrial natriuretic peptide levels were from pulmonary artery samples. cGMP = pulmonary artery cyclic guanylate monophosphate concentration; CI = cardiac index; mPAP = mean pulmonary arterial pressure; mSAP = mean systemic arterial pressure; PVR = pulmonary vascular resistance; RAP = right atrial pressure; RVEF = right ventricular ejection fraction; SvO2 = central venous oxygen saturation.  * Survival in primary pulmonary hypertension: the impact of epoprostenol therapy. * Correlation of atrial natriuretic peptide (ANP) with baseline hemodynamic parameters. Open circles = patients with PPH; closed circles = patients with NPPH. Atrial natriuretic peptide levels were from pulmonary artery samples. cGMP =