Luminal B型乳腺癌的治疗及其靶点的研究进展.pdf

中国癌症杂志 2015年第25卷第7期 《 》 CHINA ONCOLOGY 2015 Vol.25 No.7 555 Luminal B型乳腺癌的治疗及其靶点的 研究进展 孙运坡 综述　应学翔，何萍青 审校 上海交通大学附属第六人民医院普外科，上海 200233 　　［摘要］　根据基因表达谱的不同，乳腺癌被分成4种不同的亚型：基底样型、人类表皮生长因子受体 2(HER-2)过表达型、Luminal A型和Luminal B型。尽管Luminal型乳腺癌存在相似之处，但研究发现Luminal A 型和Luminal B型乳腺癌是两种不同的实体。Luminal B型乳腺癌激素受体低表达，该类型乳腺癌预后相对较 差，对化疗及内分泌治疗的反应不同。该文回顾了Luminal B型乳腺癌对化疗及内分泌治疗不同反应的临床依 据，以及目前正在研究的新的治疗靶点。 　　 ［关键词］　乳腺癌；Luminal B型；治疗；靶点 　　DOI: 10.3969/j.issn.1007-3969.2015.07.011 　　 中图分类号：R737.9　　文献标志码：A　　文章编号：1007-3639(2015)07-0555-06 Research progress of treatment and therapeutic target for Luminal B breast cancer SUN Yunpo, YING Xuexiang, HE Pingqing (Department of General Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233,China) Correspondence to: HE Pingqing E-mail: hpq0916@ Abstract Breast cancer can be classified into 4 intrinsic subtypes by gene expression profiling: basal-like, 　　［ ］ HER-2-positive, Luminal A and Luminal B. Although Luminal cancers share similarities, the studies showed that Lu- minal A and B breast cancers should be perceived as distinct entities. Luminal B breast cancer has lower expression of hormone receptors, and it also exhibits worse prognosis and has a distinct profile of response to chemotherapy and en- docrine therapy. This review presented the available clinical evidence for chemotherapy and endocrine therapy patterns of response, and potential targets for treatment. Key words Breast cancer; Luminal B subtype; Treatment; Target 　［ ］ 　　迄今为止，被公认的乳腺癌分子分型主要有 化治疗提供非常重要的依据。 4类：基底样型、HER-2过表达型、Luminal A型 　　Ki-67抗原是细胞核内分裂增殖相关蛋白， 和Luminal B型。由于基因分型在临