新生儿先天性甲状腺功能低下症的筛查与治疗评估.doc

新生儿先天性甲状腺功能低下症的筛查与治疗评估 窖l用卜I.谇京刍第21卷第2期2oo6年1月JApplClinPediatr.Vo1.21No.2January2006 770—776. 12JItoT,UdakaN,YazawaT,eta1.Basichelix一1cop—helixtranscrip— tionfactorsregulatetheneuroendocrinedifferentiationoffetalmouse pulmonaryepithelium[J]./~ve/opment,2000,127:3913—3921. 【3JFavreCJ,MancusoM,MaasK,eta1.Expressionofgenesinvolvedin vasculardevelopmentandangiogenesisinendothelialcellsofadultlung lJ].AmJPhy~olHeartarcPh3~iol,2003,285:1917—1938. [4]TaichrmnDB,IKM,Schachtner,eta/.Notch1andJ~edl.(一 pr1bythedevdorangplllIyvaseulature[J].z,2002, 225:166—175. . [5]钱莉玲,常立文,容志惠,等.维甲酸治疗新生大鼠高氧肺发育受抑 对肺组织基质金属蛋白酶及其组织抑制剂表达的影响[J].实用儿 科l临床杂志,2002,17(6):602—604. . [6]刘汉楚,常立文,容志惠,等.胰岛素样生长因子结合蛋白2在新生 鼠肺发育中的作用[J].实用儿科临床杂志,2005,20(4):303—305. [7]McMurtryIF.Introduction:pre—andpostnatallungdevelopment, maturation,andplasticity[J].AmJPhysiolLungCellMolPhysiol, ? 73? 2o02.282:341—344. 18]McCrightB,OaoX,ShenL,eta1.Defectsindevelopmentofthekid— ney,heartandeyevaseulatureinmicehomozygousforahypomorphic Noteh2mutation[J].Deve/opment,2001,128:491—502. 19JKrebsLT,XueY,NortonCR,eta1.Notchsignallngis~zentialfor vascularmorphogenesisinr~ce[J].(Dev,2000,14(11):1343— 1352. I10JMacKenzieFP,DuriezB,I.~liveeL,eta1.Notch4一inducedinhibi— tionofendothelialsproutingrequirestheankyrinrepeatsandinvolves sigr~ingthroughRBP—J[J].B/ood,2004,104:1760—1768. [11]LeongKG,HuX,LiL,eta1.ActivatedNotch4inhibitsangiogene— sis:roleofbeta1一integrinactivation[JJ.MolCelzB,2002,22: 2830—2841. [12]GomiT,KimuraA,AdriaensenD,eta1.Stagesinthedevelopment oftheratlung:morphometric,lightandelectronmicroscopicstudies [J].KaibogakuZassh,1994,69(4):392—405. (本文编辑:王家勤J 新生儿先天性甲状腺功能低下症的筛查与治疗评估?论着? 陈肖肖,毛华庆,梁黎,曹莉佩,施玉华,周雪莲,由一平,王旭,赵正言 (浙江大学医学院附属儿童医院,杭州310003) EvaluationofTherapyandScreeningforCongenitalHypothyroidisminNeonates CHENXiao—xiao,MAOHua—qing,LIANGLi,CAOLi—,SHIYu—hua,ZHOUXue—lian,QUYi一ng,WANG Xu,ZHAO~zeng—yah (ChildrensHospitalMfiliatedtoMedicalCollegeofZhejiangUniversity,Hangzhou310003,China) Abstract:ObjectiveToevaluatetheefficacyoft