Isoquinolinealkaloids异喹啉生物碱.ppt

Natural extract on powdered carrier 植物提取物 Extract of Macleaya cordata 博落回提取物 Dosage: 20-60 g/t feed 剂量：每吨饲料添加20-60克 Main effects 主要作用 Mild antimicrobial strong anti-inflammatory effect轻微的抑菌与很强的抗炎效果 Used as major component in oral healthcare products用作口腔保健产品中的主要成份 Isoquinoline Alkaloids 异喹啉生物碱 Benzophenanthridine alkaloids 苯并啡啶类生物碱 Protopine alkaloids 原阿片碱 Isoquinoline Alkaloids 异喹啉生物碱 Post-AGP strategies Isoquinoline alkaloids Mode of action 作用机理 Efficacy in pigs Conclusion NF-κB DNA Ribosome 核糖体 Cytokines 细胞因子 Receptors 受体 Mode of Action: Inhibition of NF-κB 作用机理：抑制NF-kB ? Inhibition of NF-κB activation 抑制NF-kB激活 Chaturvedi et al., 1997 Isoquinoline alkaloids异喹啉生物碱 Anti-Inflammatory Effect of Isq. Alkaloids异喹啉生物碱抗炎效果 Niewold, 2013 Down-regulation of inflammatory markers in IPEC-J2-cells infected with E. coli 负性调节受大肠杆菌感染猪空肠上皮细胞的炎症标志物 a,b,c (p0.001) *ASA = Acetyl salicylic acid 乙酰水杨酸(0.001%) FCR 饲料转化率 (n=12) Inflammation marker in jejunum: 空肠炎症标志物iNOS (n=12) 诱导型一氧化氮合酶 （n=12) (=inducible nitric oxide synthase) Linear effect of Sangrovit? vs. Control (p0.01) Effect of OTC vs. Control (p0.01) *Oxytetracycline in feed 饲料中土霉素 200 mg/kg Isq. Alkaloids (mg/l) Isq. Alkaloids (mg/l) Anti-Inflammatory Effect of Isq. Alkaloids异喹啉生物碱抗炎效果 Khadem, Niewold et al., 2014 University of Leuven, Belgium Linear effect of Sangrovit? vs. Control (p0.01) Effect of OTC vs. Control (p0.01) Acute phase protein of weaning piglets (age: 28-70 days) (n=72) 断奶仔猪急性期蛋白 （28-70日龄） a,b (p0.05) Kantas et al., 2014 Anti-Inflammatory Effect of Isq. Alkaloids异喹啉生物碱抗炎效果 Post-AGP strategies Isoquinoline alkaloids Mode of action Efficacy in pigs 猪用效果 Conclusion 采食量 Feed intake ? +2.8% 日增重 Daily gain ? +6.3% 料肉比 FCR ? -3.8% Performance (%) vs. Control Piglets生产性能（%）对比对照组仔猪 Reduced Stress Prior to Slaughter屠宰前减少应急 Artuso-Ponte, 2014 Ohio State University, USA Control 对照 Isq. alkaloids in feed 饲料中异喹啉生物碱 Isq. alkaloids in feed water 饲料与水中异喹啉生物碱 Salivar