氧化石墨烯纳米载体的生物相容性研究进展-中国现代应用药学.pdf

氧化石墨烯纳米载体的生物相容性研究进展  1 1 1 2 3* 俞文英 ，余陈欢 ，方杰 ，徐骏军 ，孙洁胤 (1.浙江省医学科学院，杭州 310013 ；2.浙江大学医学院附属第二医院，杭 州 310052 ；3.浙江医药高等专科学校，浙江 宁波 315100) 摘要：氧化石墨烯是一种石墨烯的含氧衍生物，作为新型碳纳米材料，氧化石墨烯具有高载药能力、高度可修饰性及独 特的光学性质等特性，在药物传递、生物成像及光热治疗等方面表现出了巨大的应用潜力。然而，随着氧化石墨烯在生 物医学领域的广泛研究，其生物相容性问题成为其进入临床应用的主要障碍。基于此，本文系统综述了氧化石墨烯在体 外和体内的生物相容性，以及表面修饰如何影响其在体内外的毒性。通过分析氧化石墨烯的理化性质、使用剂量和表面 修饰等对细胞和实验动物毒性的影响，为开发高效、安全的新型纳米载体提供参考。 关键词：氧化石墨烯；药物递送；生物相容性；肿瘤；光动力疗法 中图分类号：R945 文献标志码：A 文章编号：1007-7693(2017)05-0777-06 DOI: 10.13748/ki.issn1007-7693.2017.05.034 引用本文：俞文英, 余陈欢, 方杰, 等. 氧化石墨烯纳米载体的生物相容性研究进展[J]. 中国现代应用药学, 2017, 34(5): 777-782. Research Progress on Biocompatibility of Graphene Oxide as a Nanocarrier 1 1 1 2 3* YU Wenying , YU Chenhuan , FANG Jie , XU Junjun , SUN Jieyin (1.Zhejiang Academy of Medical Sciences, Hangzhou 310013, China ; 2.The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310052, China; 3.Zhejiang Pharmaceutical College, Ningbo 315100, China) ABSTRACT: Graphene oxide is a kind of oxygenated derivative of grapheme, as a new type of carbon nanomaterial, it has various characteristics: high drug loading capacity, high ability of being modified, and unique optical property, thus it shows great application potential in the aspects of drug delivery, bio-imaging, photothermal therapy, and so on. However, with more and more researches of graphene oxide in the biomedical field, its biocompatibility becomes a main obstacle for its clinical application. Therefore, this paper reviews the biocompatibility of graphene oxide in vitro and in vivo, and how its toxicity in vitro and in vivo is influenced by the surface modifier. Through analyzing the influence of such