抗高血压药物治疗06 1 6英文.ppt

Antihypertensive’s drug therapy Department of cardiology medicine 一、Goals of antihypertensive drug treatment 二、Principles of antihypertensive drug treatment 三、Antihypertensive drugs （一）Diuretics Thiazide, Loop diuretics, Potassium-sparing diuretics. （二）Beta-adrenergic receptor blockers （三）Calcium Channel Blockers （四）Renin-Angiotensin converting enzyme Inhibitors（ACEI） （五）Angiotensin ⅡReceptor Blocking （ARB）Agents （六） Alpha-adrenergic receptor antagonists （七）Vasodilators、 Other drugs 四、Effective drug combinations 一、Goals of antihypertensive drug treatment （抗高血压治疗目标） The treatment of hypertension is aimed not at the simple reduction of blood pressure but at the prevention and to achieve the maximum reduction in the total risk of the cardiovascular morbidity and mortality. As the relationship between cardiovascular risk and blood pressure is continuous, without a lower threshold低限, the goal of antihypertensive therapy should be to restore blood pressure to levels defined as “normal” or “optimal”. It would seem desirable to achieve optimal or normal blood pressure in young, middle-aged or diabetic subjects (below 130/85mmHg) and at least high normal blood pressure in elderly patients(below 140/90mmHg millimeter mercury). 二、Principles of antihypertensive drug treatment （抗高血压药物治疗原则） there is general agreement on the principles governing the use of antihypertensive drug to lower blood pressure, independent of the choice of particular drugs. These principles include: 1、 The use of low doses of drugs to initiate therapy （初始治疗使用低剂量） Beginning with the lowest available dose of the particular agent, in an effort to reduce adverse effects. If there is a good response to a low dose of a single drug but the pressure is still short of adequate control, it is reasonable to increase the dose of the same drug, provided that it has been well tolerated好的接受. 2、The use of appropriate drug