对氟苯酚的合成工艺研究.pdf

4 , : ·43 · Synthesis of 4-Aminopyridine by Catalytic Transferhydrogenation Method XUE Yong,HU Xiao-chun, DONG Zhong-chao, ZHOU Li-ming, FAN Qi-ping (Research Institute, Institute of Chemical Def ence, B eij ing 102205, China ) Abstract:The tit e compound was obtained from 4-aminopyridine-1-oxide by cata ytic transferhydrogenation reduction in the presence of HCOONH -Pd/C at atmospheric pressure in 90%yie d.The compound was characterized by me ting 4 point, GC-MS spectrometry .The reaction condition is mi d,without environmenta po ution. Key words:4-nitropyridine-1-oxide;4-aminopyridine;ammonium formate;cata ytic transferhydrogenation Foundation item:Granted by the 98 youth funds of chemica defence institute of the PLA (98-5) 1 2 1 1 刘加庚, 孙维林, 徐端均, 徐元植 (1. (), 　310027;2. (), 　310027) :。 , , , , 。 , 130 ℃, 80%, 90 % 。 :;; :TQ 243.3 　　:A 　　:1003-5214(1999)04-004 3-04 　　 -, , 、 , [1, 2] 、 。 。, , 。, [3, 4] (cepha osporin ) , 。 [5 ～7] 。, -, [ 8, 9] 。 , , -、 。 [1, 10] -、- 。 , -, 。 , 。 , , , , , 。 。 , 。, 30%。 ·44 · 　FINE CHEMICALS 1999 　 16 , 1　 。35 ～38g, 1.1　 80%～ 85%(), HPLC , 、, 99%。 。