一种治疗顽固性高血压新的方法经导管肾神经消融蒋雄京.ppt

一种治疗顽固性高血压的新方法:经导管肾神经消融;Background ? Hypertension is a global public health problem of major magnitude ? An estimated 30-40% of the adult population in the developed world suffers from this condition. ? Despite numerous safe and effective pharmacological therapies, only~50% of patients achieve blood pressure control to guideline targets ? Renal sympathetic efferent and afferent nerves, which lie in the wall of the renal artery, have been recognized as seminal in the initiation and maintenance of systemic hypertension;Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study. Lancet 2009; 373: 1275–;More information;Symplicity HTN-2: Denervation effective for treating resistant hypertension Lancet 2010; Advance online A group of 100 patients who, despite taking three or more antihypertensive drugs, had a baseline systolic BP of ≥160 mm Hg – ≥150 mm Hg for type 2 diabetics – were randomly assigned to ;Novel therapeutic targets for hypertensionLudovit Paulis, Thomas UngerNature Reviews Cardiology 7, 431-441 (August 2010) ? ;Thanks Thanks Thanks Thanks Thanks Thanks