一种调控脂解的重要蛋白围脂滴蛋白.pdf

ISSN 2006 12 CN 113870Q Chinese Journal of Biochemistry and Molecular Biolo y 22( 12) : 931~ 934 综述 (Perilipin) * 张利红, 张立杰, 杨公社 ( 西北农林科技大学动物脂肪沉积与肌肉发育实验室, 陕西 杨凌 712100) 围脂滴蛋白( perilipin) 是脂滴相 蛋白家族的核心成员之一, 是定位于脂滴表面的高磷酸化 的蛋白, 对脂肪组织中甘油三酯的代谢有双重调节作用, 既可通过阻止脂肪酶接近脂滴降低基础状 态下的脂解, 又可促进激素刺激的脂肪分解. Perilipin 在脂代谢中发挥重要作用, 其表达调控可能与 肥胖及其相 代谢疾病如糖尿病胰岛素抵抗等有重要 系. 本文主要介绍了perilipin 的发现命 名结构特征以及激素和转录因子对perilipin 的调控, 并阐述了其与相 脂肪酶间的相互作用. 目 前的研究主要集中于围脂滴蛋白( perilipin) 和激素敏感脂肪酶(HSL) 之间, 与新近发现的脂肪酶脂 肪三酰甘油脂酶(ATGL) 的相互作用则有待于进一步研究. 围脂滴蛋白; 激素敏感脂酶; 脂肪三酰甘油脂酶; 脂肪分解 + Q513 3 Perilipin:One Important Protein in Lipolysis Regulation * ZHANG LiHon , ZHANG LiJie, YANG Gon She ( Laboratory of Animal Fat Deposition and Muscle Development , Northwest AF University, Yangling 712100, Shaan i, China) Abstract Perilipin is one of the major members in PAT ( perilipin, ADRP, TIP47) protein family, whose members not only have similar sequences but also have similar ene structure. It is a hi hly phosphorylated adipocyte protein which locates at the surface of the lipid droplet . It serves important functions in double re ulatin triacyl lycerol metabolism by blockin lipase approachin droplets to reduce rates of basal lipolysis and facilitate hormonally stimulated lipolysis, then re ulates the stora e and release of TG. Perilipin plays a important role in lipid metabolism. Its expression and re ulation may be associated with obesity and related disorders such as diabetes, atheroma and insulinresistance. This review mainly introduc