兽用抗菌药耐药判定标准的研究进展.pdf

中国抗生素杂志年月第卷第期 . 667 . 文章编号：-()-- 兽用抗菌药耐药判定标准的研究进展 房诗薇 黄玲利 谢书宇 王玉莲 瞿玮 程古月 刘振利 袁宗辉 郝海红* ( 华中农业大学国家兽药残留基准实验室(HZAU) ，农业部兽药残留检测重点实验室，武汉) 摘要：兽用抗菌药因其可以有效地预防和治疗动物疾病而被广泛使用，造成了严重的细菌耐药。目前，兽药抗菌药的耐药 判定主要参考美国临床和实验室标准协会(CLSI) 和欧盟药敏试验标准委员会(EUCAST) 公布的标准，但数据并不完整。我国近 些年也开始建立适合自己国情的兽用抗菌药的耐药判定标准，但成果并不多。因此，急需建立和完善兽用抗菌药的耐药判定标准， 以便于监测兽用抗菌药耐药性和指导临床准确使用兽用抗菌药。本文主要综述了CLSI 和EUCAST 两大组织已经公布的部分兽 用抗菌药的耐药判定标准，以及近年来国内外兽用抗菌药耐药判定标准的研究进展，以期为兽用抗菌药耐药判定标准的发展提 供理论参考。 关键词：兽用抗菌药；美国临床和实验室标准协会；欧盟药敏试验标准委员会；耐药判定标准 中图分类号：R 文献标志码：A Study progress on breakpoints of veterinary antibiotics Fang Shi-wei, Huang Ling-li, Xie Shu-yu, Wang Yu-lian, Zhai Wei, Cheng Gu-yue, Liu Zhen-li, Yuan Zong-hui and Hao Hai-hong (national reference Laboratory of veterinary drug residue (HZAU), key Laboratory for the detection of veterinary drug residue in Food of ministry of Agriculture, Huazhong Agricultural University, Wuhan 430070) Abstract In veterinary medicine, antimicrobial agents are extensively used for the treatment of animal diseases, which results in the development of bacterial resistance. However, the Clinical Laboratory Standard Institute (CLSI) and the European Committee of Antimicrobial Susceptibility Testing (EUCAST) still lack the clinical breakpoints for some antimicrobial agents against special bacteria in veterinary medicine. The establishment of clinical breakpoints of antimicrobial agents in China was initiated in recent years and largely lacked clinical breakpoints of veterinary antimicrobial agents. It is essential to develop some critically important antimicrobial agents against some important pathogens to provide criteria and standards for the surveillance of antim