镰刀形红血球贫血症-精选课件(公开).pptVIP

Genetic Diseases (1)Sickle-cell anaemia 鐮刀形紅血球貧血症 Introduction of Sickle-cell anaemia It is a genetic diseases the patient’s red blood cells are rigid sickle in shape common disaeses in African two copies of the haemoglobin gene in every cell of our body a recessive condition because they have two copies of the sickle haemoglobin gene to have the disorder. Problems of Sickle-cell anaemia Less oxygen are be carried these sickle cell are weak and have shorter life span lead to small blood vessels getting blocked lead to severe pain and damage to organs such as liver, kidney, lungs, heart and spleen. Death can be a result. Explaination of blocking blood vessels The Genetic Combination (1)Sickle Cell Trait and Unaffected none of the children will have sickle cell anaemia. a one in two (50%) chance that any given child will get one copy of the HbS gene and therefore have the sickle cell trait. The Genetic Combination (2) Sickle Cell Trait and Sickle Cell Trait (25%) chance that any given child could be born with sickle cell anaemia. (25%)chance that any given child could be completely unaffected The Genetic Combination (3) Sickle Cell Trait and Sickle Cell Anaemia a one in two (50%) chance that any given child will get sickle cell trait and a one in two chance that any given child will get sickle cell anaemia. The Genetic Combination (4)Sickle Cell Anaemia and Unaffected all the children will have sickle cell trait. None will have sickle cell anaemia. Genetic Diseases (2) Haemophilia 血友病 Introduction of Haemophilia a lifelong inherited genetic disease Haemophilia (Greek)=“love of blood” Hemorrhaephilia=“The love of hemorrhage” (hemorrhage=bleeding) an essential clotting factor is either partly or completely missing causes a patient to bleed for longer than normal. Threes types of Haemophilia Haemophilia A (80%) lacks clotting factor 8 Haemophilia B(20%) lacks clotting factor 9 Haemophilia C lacks clotting factor 11 Why Haemophilia patient bleeding seriously F