ncic药物副反应分级.doc

CTC Version 2.0 Publish Date: April 30, 1999 COMMON TOXICITY CRITERIA (CTC) Grade Adverse Event 0 1 2 3 4 ALLERGY/IMMUNOLOGY Allergic reaction/ hypersensitivity (including drug fever) none transient rash, drug fever 38°C (100.4°F) urticaria, drug fever ≥38°C (≥100.4°F), and/or asymptomatic bronchospasm symptomatic bronchospasm, requiring parenteral medication(s), with or without urticaria; allergy-related edema/angioedema anaphylaxis Note: Isolated urticaria, in the absence of other manifestations of an allergic or hypersensitivity reaction, is graded in the DERMATOLOGY/SKIN category. Allergic rhinitis (including sneezing, nasal stuffiness, postnasal drip) none mild, not requiring treatment moderate, requiring treatment - - Autoimmune reaction none serologic or other evidence of autoimmune reaction but patient is asymptomatic (e.g., vitiligo), all organ function is normal and no treatment is required evidence of autoimmune reaction involving a non- essential organ or function (e.g., hypothyroidism), requiring treatment other than immunosuppressive drugs reversible autoimmune reaction involving function of a major organ or other adverse event (e.g., transient colitis or anemia), requiring short-term immunosuppressive treatment autoimmune reaction causing major grade 4 organ dysfunction; progressive and irreversible reaction; long-term administration of high- dose immuno- suppressive therapy required Also consider Hypothyroidism, Colitis, Hemoglobin, Hemolysis. Serum sickness none - - present - Urticaria is graded in the DERMATOLOGY/SKIN category if it occurs as an isolated symptom. If it occurs with other manifestations of allergic or hypersensitivity reaction, grade as Allergic reaction/hypersensitivity above. Vasculitis none mild, not requiring treatment symptomatic, requiring medication requiring steroids ischemic changes or requiring amputation Allergy/Immunology - Other (Specify, __________) none mild moderate severe life-threatening or disabling AUDITOR