警惕PPI长期使用安全性.ppt

警惕PPI长期使用的安全性 W ARTICLe Guide to the Use of Proton Pump Inhibitors in adult patients andan Boparai, Jaishree Rajagopalan and George Triadafilopoulos Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stan ford California usa Content Abstract Proton Pump Inhibitors(PPD) 1.2 Delayed-Release, Immediate-Release and Intravenous PPls .3 Metabolism and Drug Interactions 2.1 Over-The-Counter and On-Demand PPl Use ,..929 2.2 Uninvestigated Gastro-Oesophageal Reflux Disease(GORD) 2.3 Treatment of Symptomatic GORD.... 2.4 Maintenance of GORD Symptom Relief 932 2.5 Maintenance of Healing of Erosive Oesophagitis 932 2.6 Treatment of Symptomatic, Non-Erosive Reflux Disease 932 2.7 Refractory Heartburn 933 2.8 Nocturnal GORD 933 oona ctures 2.10 Barmetts Oesophagus 934 2, 11 Extra-Oesophageal Manifestations of GORD ,,,935 2. 12 PPl-Based GORD Treatment Paradigm 935 2. 13 Peptic Ulcer Disease 936 2.14 PPls for Aspirin- and NSAID-Associated Ulcers and Complications 2.15 Risk of duodenal Ulcer recurrence 938 2.16 Healing of NSAID-Associated Gastric Ulcers 938 2. 17 Hellcobacter pylori Eradication to Reduce the Risk of duodenal Ulcer Recurrence 2. 18 Non-Variceal Upper Gastrointestinal(GI)Bleeding 939 2.19 PPl Therapy for Bleeding Ulcers 2.20 Overall Approach to Endoscopic/Pharmacological Treatment of Bleeding Ulcers,,,,.940 222 Reduction of Risk of Upper GI Bleeding in Critically Il Patients,………………………940 2.21 PPl Therapy of Pathological Hyper-Secretory Condition 2.23 Dyspepsia 941 Number of PPl safety articles published 16 8642 Year GASTROENTEROLOGY 2010: 139: 1115-1127 ④中学论M报20053月Am6tbne120:S针对酸治疗铝关不 抑酸治疗:不良反应知多少 抑酸剂为消化系统疾病治疗带来了里程碑式进步, 但其潜在副作用同样不可忽视 铁吸收 肺炎 中国医学论坛报,2009年6月11日