基础免疫学基础免疫学1Cellular Innate Immunity_ An Old Game with New Players.pdf

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2020-08-08 发布于广东
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基础免疫学基础免疫学1Cellular Innate Immunity_ An Old Game with New Players.pdf

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Review Journal of Innate J Innate Immun 2017;9:111–125 Received: November 11, 2016 Immunity DOI: 10.1159/000453397 Accepted after revision: November 14, 2016 Published online: December 23, 2016 Cellular Innate Immunity: An Old Game with New Players Georg Gasteiger a Andrea D’Osualdo e David A. Schubert e Alexander Weber b Emanuela M. Brusciad Dominik Hartl c, e a Institute of Medical Microbiology and Hygiene, University of Freiburg, Freiburg Medical Center, Freiburg, b Department of Immunology, Interfaculty Institute for Cell Biology and c Children’s Hospital and Interdisciplinary Center for Infectious Diseases, University of Tübingen, Tübingen , Germany; d Section of Respiratory Medicine, Department of Pediatrics, Yale University School of Medicine, New Haven, CT , USA; e Roche Pharma Research and Early Development (pRED), Immunology, Inflammation and Infectious Diseases (I3) Discovery and Translational Area, Roche Innovation Center Basel, Basel , Switzerland Keywords Innate Immunity Host defense · Immune response · Neutrophils · Pattern recognition receptors · Phagocytosis · Toll-like receptor · The innate immune system is an evolutionarily con- Innate Immunity · Myeloid-derived suppressor cells · Innate served host defense system with key features being shared lymphoid cells · Macrophages between plants, invertebrates, and mammals [1, 2] . In-