基础免疫学macrophage review基础免疫学基础免疫学1.pdf

Clinical Science (2017) 131 1329–1342 DOI: 10.1042/C Review Article A past and present overview of macrophage metabolism and functional outcomes 1* 1* ´ 2 3,4 Rui Curi , Renata de Siqueira Mendes , Luiz Aurelio de Campos Crispin , Giuseppe Danilo Norata , Sandra Coccuzzo Sampaio2,5 and Philip Newsholme3 1 ˜ 2 Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes, 1524, SP 05508-900, Brazil; Laboratory of ˜ 3 Pathophysiology, Butantan Institute, Av. Vital Brazil, 1500, SP 05503-900, Sao Paulo, Brazil; School of Biomedical Sciences, Curtin Health Innovation Research Institute (CHIRI), Curtin University, Perth, WA, Australia; 4 ` 5 Department of Pharmacological and Biomolecular Sciences, Universita degli Studi di Milano, Milan, Italy; Department of Pharmacology, ˜ Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes, 1524, SP 05508-900, Brazil Correspondence: Philip Newsholme (Philip.Newsholme@.au) In 1986 and 1987, Philip Newsholme et al. reported macrophages utilize glutamine, as well as glucose, at high rates. These authors measured key enzyme activities and consumption and production levels of metabolites in incubated or cultured macrophages isolated from