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REVIEW
published: 07 June 2019
doi: 10.3389/fimmu.2019.01197
IL-1 Family Members in Cancer; Two
Sides to Every Story
1,2,3 2,4† 1,4 †
KevinJ.Baker ,AileenHouston andElizabethBrint *
1 Department of Pathology, University College Cork, Cork, Ireland, 2 Department of Medicine, University College Cork, Cork,
Ireland, 3 APC Microbiome Ireland, University College Cork, Cork, Ireland, 4 CancerResearch@UCC, University College Cork,
Cork, Ireland
The IL-1 family of cytokines currently comprises of seven ligands with pro-inflammatory
activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ) as well as two ligands with
anti-inflammatory activity (IL-37, IL-38). These cytokines are known to play a key role in
modulating both the innate and adaptive immunes response, with dysregulation linked to
a variety of autoimmune and inflammatory diseases. Given the increasing appreciation of
the link between in
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