基础免疫学基础免疫学1 Dendritic Cell Subsets.pdf

Immunity Review Development and Function of Dendritic Cell Subsets Alexander Mildner1 and Steffen Jung1,* 1Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel *Correspondence: s.jung@weizmann.ac.il /10.1016/j.immuni.2014.04.016 Classical dendritic cells (cDCs) form a critical interface between innate and adaptive immunity. As myeloid immune cell sentinels, cDCs are specialized in the sensing of pathogen challenges and cancer. They translate the latter for T cells into peptide form. Moreover, cDCs provide additional critical information on the original antigen context to trigger a diverse spectrum of appropriate protective responses. Here we review recent progress in our understanding of cDC subsets in mice. We will discuss cDC subset ontogeny and transcrip- tion factor dependencies, as well as emerging functional specializations within the cDC compartment in lymphoid and nonlymphoid tissues. Introduction MHC-II-expressing non-B cells have been identified in almost The vertebrate immune system evolved to react to infection and every tissue investigated, including the intestine, heart, and injury caused by bacteria, fungi, viruses, and immunogenic kidney, with the notable exception of the brain parenchyma. All particles (collectively referred to here as antigens [Ags]) by DCs share the capability to efficiently uptake and process Ags mounting protective immune responses that improve survival. for presentation to naive T cells. However, in the decades since The highly diverse Ag receptor repertoire required for this broad Steinman’s seminal discovery, DC subsets have emerged that and almos