基础免疫学基础免疫学1Antibody-cytokine fusion proteins for improving efficacy and safety of cancer therapy.pdf

Biomedicine Pharmacotherapy 95 (2017) 731–742 Available online at ScienceDirect Review Antibody-cytokine fusion proteins for improving efficacy and safety of cancer therapy a,b a,b a,b,* a,b,* Zahra Valedkarimi , Hadi Nasiri , Leili Aghebati-Maleki , Jafar Majidi a Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran b Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran A R T I C L E I N F O A B S T R A C T Article history: Received 5 May 2017 Cytokines are key players in the regulation of immune responses both in physiological and pathological Received in revised form 25 July 2017 states. A number of cytokines have been evaluated in clinical trials and shown promising results in the Accepted 30 July 2017 treatment of different malignancies. Despite this, the clinical application of these molecules may be plagued by undesirable side effects The development of recombinant antibody–cytokine fusion proteins, Keywords: which offer a means for target delivery of cytokines toward the tumor site, has significantly improved the Antibody–cytokine fusion proteins therapeutic index of these immunomodulatory molecules. Selective tumor localization is provided by the Cancer