系统病理学 (34)系统解剖学.pdf

Parasitosis n Definition Ø Caused by parasites Ø Factors reltated to transmission l Physical factors: local geography, climate, season, etc. l Bilological factors: host, biotic habitat,vector, etc. n Epidemiology Ø Common disease worldwide Ø Tropic and subtropic areas Ø Poor sanitation n Entamoeba histoly tica Ø Cystic form l Infection, stools l Transmission by fecal-oral route Ø Trophozoite form l Tissue injury, host and fresh stools l Release lytic enzymes and pore-forming proteins, and recruit neutrophils n Involved tissues n Intestinal amoebiasis Ø Acute phase: Amoebic dysentery Ø Chronic phase: Amoeboma Development of flask-shaped ulcer in the intestine Intestinal amoebiasis Intestinal amoebiasis Amoebic liver abscess A B C A-Liver specimen, B-Histological figure from the lesion, C-Thick pus like chocolate sauce from the liver puncture n Diagnosis Ø Contact history with contaminated water or food Ø Clincal manifestations Ø Clinical testing l Stool test l HE staing Trophozoite l PAS staining in stool l Hemagglutination testing n Brief overview Ø Dioecious trematodes -genus Schistosoma Ø Exposure to the water with cercariae Ø Intestinal tract and liver n Geographic distribution of schistosome Ø S. haematobium Northern Africa Ø S. j ap onicum Asia Ø S. mansoni Africa/the Middle East/South America/Some Caribbean countries n Etiology n Pathogenesis Ø Antigenicity Ø