分子营养学——营养素与药物的相互作用.pdf

第三章营养素与药物的相互作用 天津大学农学院食品科学系 Food Nutrients-Drug Interactions Food Nutrients-Drug Interactions Food Nutrients-Drug Interactions Introduction Physical and chemical interaction between food and drug Physical and chemical interaction between food and drug Interaction on absorption between food and drug Interaction on bioavailability and metabolism of food and drug Interactions of food and drug under special condition Summary Questions 第一节 概述 Introduction Drug-Nutrient Interactions, Food-drug interactions can be a result of different mechanisms and lead to a decrease in drug efficacy or increases toxicity. The main way that food and drugs interact are: Some foods may affect how a drug is absorbed. The drug may go into the body faster or slower or more or less of the drug may be absorbed. A food may also alter how a drug works. It may make it last a longer or shorter time in your body or may make it not have the desired effect on your medical condition. Similarly , drugs can change how a food or vitamin or mineral is absorbed or metabolized by the body. Finally a drug may make you feel more or less hungry than usual. Possible Drug-Food Interactions means food can affect drug absorption and can interfere with how a drug works; A drug may affect food absorption or how vitamins or minerals are used by the body, and a drug can affect appetite then influence how the nutrients works. It includes two form of interactions 1) Drug-Nutrient Interactions Medications, prescription and over-the-counter, can affect how the body uses nutrients. For individuals taking medications for long periods of time drug- nutrient interactions may lead to vitamin or mineral deficiencies. Medications can affect nutritional health by causing poor food intake. Medications can decrease appetite, or cause nausea, vomiting, unpleasant taste or dry mouth. Medications c